Magnetic resonance imaging phenotyping of Becker muscular dystrophy

Neda Faridian-Aragh, Kathryn R. Wagner, Doris G. Leung, John A. Carrino

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: There is little information on magnetic resonance imaging (MRI) phenotypes of Becker muscular dystrophy (BMD). This study presents the MRI phenotyping of the upper and lower extremities of a large cohort of BMD patients. Methods: In this retrospective study, MRI images of 33 BMD subjects were evaluated for severity, distribution, and symmetry of involvement. Results: Teres major, triceps long head, biceps brachii long head, gluteus maximus, gluteus medius, vasti, adductor longus, adductor magnus, semitendinosus, semimembranosus, and biceps femoris muscles showed the highest severity and frequency of involvement. All analyzed muscles had a high frequency of symmetric involvement. There was significant variability of involvement between muscles within some muscle groups, most notably the arm abductors, posterior arm muscles, medial thigh muscles, and lateral hip rotators. Conclusions: This study showed a distinctive pattern of involvement of extremity muscles in BMD subjects.

Original languageEnglish (US)
Pages (from-to)962-967
Number of pages6
JournalMuscle and Nerve
Volume50
Issue number6
DOIs
StatePublished - Dec 1 2014

Keywords

  • Becker muscular dystrophy
  • Fatty infiltration
  • Lower extremity
  • MRI
  • Muscular dystrophy
  • Phenotype
  • Upper extremity

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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