Magnetic resonance imaging of uveitis

Charles Q. Li, Aaron A. Cho, Neeraj J. Edward, Deepak P. Edward, Roman G. Fajardo, Mahmood F. Mafee

Research output: Contribution to journalArticle

Abstract

Introduction: Uveitis is a term used to describe inflammation of the choroid, iris, or ciliary body, which make up the uveal tract. It can be idiopathic or associated with a systemic disease which may be infectious or noninfectious. With the exception of B-scan ultrasonography, current imaging methods for diagnosing and monitoring uveitis are predominately non-radiologic. Although MRI has been anecdotally shown to detect various inflammatory conditions of the globe, such as posterior scleritis, endophthalmitis, and posterior uveitis secondary to Vogt-Koyanagi-Harada disease, a more comprehensive review of the MRI findings in uveitis of various etiologies is presented here. Methods: The MRI and CT studies of seven patients with uveitis and the clinical history of three of them (not available in four patients) were reviewed. Etiologies included ankylosing spondylitis, relapsing polychondritis, Vogt-Koyanagi-Harada disease, sarcoidosis, and tuberculosis. Results: Increased gadolinium enhancement of the uveal tract, which is visualized as the enhancing layer immediately deep to the low-signal sclera, was seen on all six MRI studies. Diffusion-weighted imaging of a case with posterior uveitis and subretinal effusions revealed restriction within the uvea and effusions. Two patients had inflammatory nodules adherent to the uvea, two patients had vitreous humor abnormalities, and one patient exhibited proximal perineural and perimuscular spread of enhancement. Uveoscleral thickening and enhancement with a posterior calcification were observed in the patient with chronic uveitis imaged with CT. Conclusions: Increased uveal tract enhancement is a common finding in patients with uveitis, regardless of anatomic distribution and etiology. MRI can also further evaluate complications of uveitis and help differentiate it from masquerade syndromes.

Original languageEnglish (US)
Pages (from-to)825-832
Number of pages8
JournalNeuroradiology
Volume57
Issue number8
DOIs
StatePublished - Apr 24 2015

Fingerprint

Uveitis
Magnetic Resonance Imaging
Posterior Uveitis
Uveomeningoencephalitic Syndrome
Uvea
Relapsing Polychondritis
Scleritis
Vitreous Body
Ciliary Body
Sclera
Endophthalmitis
Choroid
Ankylosing Spondylitis
Gadolinium
Iris
Sarcoidosis
Ultrasonography
Tuberculosis
History
Inflammation

Keywords

  • Computed tomography
  • Inflammatory conditions
  • Magnetic resonance imaging
  • Ocular disease
  • Uveitis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Li, C. Q., Cho, A. A., Edward, N. J., Edward, D. P., Fajardo, R. G., & Mafee, M. F. (2015). Magnetic resonance imaging of uveitis. Neuroradiology, 57(8), 825-832. https://doi.org/10.1007/s00234-015-1531-7

Magnetic resonance imaging of uveitis. / Li, Charles Q.; Cho, Aaron A.; Edward, Neeraj J.; Edward, Deepak P.; Fajardo, Roman G.; Mafee, Mahmood F.

In: Neuroradiology, Vol. 57, No. 8, 24.04.2015, p. 825-832.

Research output: Contribution to journalArticle

Li, CQ, Cho, AA, Edward, NJ, Edward, DP, Fajardo, RG & Mafee, MF 2015, 'Magnetic resonance imaging of uveitis', Neuroradiology, vol. 57, no. 8, pp. 825-832. https://doi.org/10.1007/s00234-015-1531-7
Li CQ, Cho AA, Edward NJ, Edward DP, Fajardo RG, Mafee MF. Magnetic resonance imaging of uveitis. Neuroradiology. 2015 Apr 24;57(8):825-832. https://doi.org/10.1007/s00234-015-1531-7
Li, Charles Q. ; Cho, Aaron A. ; Edward, Neeraj J. ; Edward, Deepak P. ; Fajardo, Roman G. ; Mafee, Mahmood F. / Magnetic resonance imaging of uveitis. In: Neuroradiology. 2015 ; Vol. 57, No. 8. pp. 825-832.
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