Magnetic resonance imaging of inflammatory myopathies

Filippo Del Grande, John A. Carrino, Maria Del Grande, Andrew L. Mammen, Lisa Christopher-Stine

Research output: Contribution to journalArticle

Abstract

The following article reviews the role of magnetic resonance imaging (MRI) in patients with idiopathic inflammatory myopathies (IIMs), focusing on the 3 major types of IIM: polymyositis, dermatomyositis, and inclusion-body myositis. After a brief introduction with general information about IIM, we will discuss the reasons why MRI plays an important role in the diagnosis and management of patients with polymyositis, dermatomyositis, and inclusion-body myositis. Magnetic resonance imaging can confirm the diagnosis and can help to phenotype the disease. Moreover, the support of MRI is important in addressing the muscle biopsy site and in reducing the high false-negative rate of biopsy when performed in a blind fashion. In monitoring therapy, MRI can add important information about the activity of the muscle disease and can identify cases where continued immunosuppressive therapy is no longer warranted owing to complete fatty replacement of the muscles. Lastly, we provide an overview about some advanced MRI techniques that focus more on function than on morphology of muscle.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalTopics in Magnetic Resonance Imaging
Volume22
Issue number2
DOIs
StatePublished - Apr 2011

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Myositis
Magnetic Resonance Imaging
Inclusion Body Myositis
Muscles
Dermatomyositis
Biopsy
Immunosuppressive Agents
Phenotype
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Magnetic resonance imaging of inflammatory myopathies. / Del Grande, Filippo; Carrino, John A.; Del Grande, Maria; Mammen, Andrew L.; Christopher-Stine, Lisa.

In: Topics in Magnetic Resonance Imaging, Vol. 22, No. 2, 04.2011, p. 39-43.

Research output: Contribution to journalArticle

Del Grande, Filippo ; Carrino, John A. ; Del Grande, Maria ; Mammen, Andrew L. ; Christopher-Stine, Lisa. / Magnetic resonance imaging of inflammatory myopathies. In: Topics in Magnetic Resonance Imaging. 2011 ; Vol. 22, No. 2. pp. 39-43.
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