Magnetic resonance imaging of cells in experimental disease models

Naser Muja, Jeff W.M. Bulte

Research output: Contribution to journalReview article

Abstract

Some of the recent advances in non-invasive cell detection that have significantly expanded the researcher's collection for monitoring the basic unit of life in its native or diseased context is presented. Exogenous bioengineered and non-mammalian factors have greatly facilitated non-invasive detection of cells in mammals. The most widely applied factors for non-invasive imaging studies consist of (super)paramagnetic metal ions, positron emitters, gamma radiation-emitting radionuclides, and low-energy photons generated by luciferase activity for MR, PET, SPECT, and BLI, respectively. MR scanners measure the harmless response of the proton in water, fat, and other endogenous biomolecules to applied radio waves in a strong homogenous magnetic field. MR microscopy is most commonly performed on cultured cells or preserved tissue samples in the absence of time constraints associated with MR imaging of living subjects.

Original languageEnglish (US)
Pages (from-to)61-77
Number of pages17
JournalProgress in Nuclear Magnetic Resonance Spectroscopy
Volume55
Issue number1
DOIs
StatePublished - Jul 1 2009

Keywords

  • Cell labeling
  • Cell therapy
  • Cell tracking
  • MR contrast agent
  • MR microscopy
  • Magnetic resonance
  • Molecular imaging
  • Nanoparticle
  • Stem cell

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Nuclear and High Energy Physics
  • Spectroscopy

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