Magnetic resonance imaging of brain iron in health and disease

Josef Vymazal, Rodney A. Brooks, Nicholas Patronas, Milan Hajek, Jeff W Bulte, Giovanni Di Chiro

Research output: Contribution to journalArticle

Abstract

Brain iron is a major contributor to magnetic resonance imaging (MRI) contrast in normal gray matter, and its role in the pathogenesis of different neurological disorders has also become apparent. Non-heme brain iron is present in the brain mainly in the form of ferritin. The unique magnetic properties of ferritin determine different signal changes on both T1- and T2-weighted images, and the T2 relaxation rates have a linear dependence on applied field strength. This finding is typical for ferric oxyhydroxide cores. The resulting T2-shortening also depends on echo-spacing used in the imaging sequence as well as on the water diffusion coefficient and the size of the ferritin cluster. Quantitation of non-heme brain iron by MRI aids in the diagnosis and monitoring of different neurological diseases.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalJournal of the Neurological Sciences
Volume134
Issue numberSUPPL.
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Ferritins
Iron
Magnetic Resonance Imaging
Health
Brain
Nervous System Diseases
Water

Keywords

  • Brain iron
  • Diffusion
  • Hallervorden-Spatz disease
  • Magnetic resonance imaging
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Aging
  • Surgery
  • Developmental Neuroscience
  • Neuroscience(all)

Cite this

Magnetic resonance imaging of brain iron in health and disease. / Vymazal, Josef; Brooks, Rodney A.; Patronas, Nicholas; Hajek, Milan; Bulte, Jeff W; Di Chiro, Giovanni.

In: Journal of the Neurological Sciences, Vol. 134, No. SUPPL., 1995, p. 19-26.

Research output: Contribution to journalArticle

Vymazal, J, Brooks, RA, Patronas, N, Hajek, M, Bulte, JW & Di Chiro, G 1995, 'Magnetic resonance imaging of brain iron in health and disease', Journal of the Neurological Sciences, vol. 134, no. SUPPL., pp. 19-26. https://doi.org/10.1016/0022-510X(95)00204-F
Vymazal, Josef ; Brooks, Rodney A. ; Patronas, Nicholas ; Hajek, Milan ; Bulte, Jeff W ; Di Chiro, Giovanni. / Magnetic resonance imaging of brain iron in health and disease. In: Journal of the Neurological Sciences. 1995 ; Vol. 134, No. SUPPL. pp. 19-26.
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