Magnetic resonance imaging measurement of posterior fossa structures in schizophrenia

Elizabeth H. Aylward, Allan Reiss, Patrick E. Barta, Allen Tien, William Han, James Lee, Godfrey D. Pearlson

Research output: Contribution to journalArticlepeer-review


Objective: Previous research has yielded conflicting results regarding the hypothesis that structural abnormalities of the cerebellar vermis and other posterior fossa structures are associated with schizophrenia. The purpose of this study was to apply techniques of measuring posterior fossa structures from magnetic resonance imaging scans that have proven reliable in identifying structural abnormalities in other patient populations. Method: Midsagittal areas of cerebellar vermis and its subsections (anterior vermis, lobules VI-VII, and lobules VIII-X), brainstem (pons, medulla, and midbrain), and fourth ventricle, as well as intracranial area and cortical area, were measured. Subjects included 36 schizophrenic patients and 51 normal comparison subjects. Groups were matched on age, sex, race, and family socioeconomic status. Results: No significant group differences were detected for any posterior fossa structure. When corrected for intracranial area, fourth ventricle area was significantly larger in patients than in the comparison group. Fourth ventricle area was not, however, correlated with any measures of symptom severity. Conclusions: The size of posterior fossa structures is not abnormal in schizophrenia.

Original languageEnglish (US)
Pages (from-to)1448-1452
Number of pages5
JournalAmerican Journal of Psychiatry
Issue number10
StatePublished - Oct 1994
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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