Abstract
Objectives: To study the association between changes in brain magnetic resonance imaging (MRI) and clinical outcomes in early MS. Methods: MS patients within 12 months of onset were enrolled and followed up to 3 years. Clinical measures included Symbol Digit Modalities Test (SDMT), MS Functional Composite (MSFC) and low contrast letter acuity (LCLA). MR] outcomes included brain volume changes measured by SIENA and SIENAX normalized measurements [brain parenchymal volume (BPV), normal-appearing white and gray matter volume (NAWMV and GMV) and T2 lesion volume (T2LV)]. Mixed model regression measured time trends and associations between imaging and clinical outcome. Results: Forty-three patients were enrolled within 7.5 ±4.9 months of onset. Baseline T2 lesion volume predicted subsequent changes in Paced Auditory Serial Addition Test (PASAT) (p=0.004), whereas baseline measures of atrophy including BPV, GMV, and NAWMV predicted longitudinal changes in MSFC (p=0.016, p=0.040, p=0.021, respectively) and Timed-25 Foot Walk (p<0.05). Each 1% decrease in SIENA was associated with 1.14 point decrease in SDMT score (p=0.03). Each 1% decrease in brain volume SIENA was associated with almost 1.5 letters decrease on LCLA (p=0.02). Conclusion: Measures of lesion volume and over all brain volume were associated with different long-term clinical out come measures in early MS.
Original language | English (US) |
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Pages (from-to) | 720-727 |
Number of pages | 8 |
Journal | Multiple Sclerosis and Related Disorders |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - 2014 |
Keywords
- Brain atrophy
- Cognition
- Magnetic resonance imaging
- Multiple sclerosis
- Neuroprotection
- Outcomes
ASJC Scopus subject areas
- Neurology
- Clinical Neurology