Magnetic resonance imaging and spectroscopy of the murine cardiovascular system

Ashwin Akki, Ashish Gupta, Robert G. Weiss

Research output: Contribution to journalReview articlepeer-review

Abstract

Magnetic resonance imaging (MRI) has emerged as a powerful and reliable tool to noninvasively study the cardiovascular system in clinical practice. Because transgenic mouse models have assumed a critical role in cardiovascular research, technological advances in MRI have been extended to mice over the last decade. These have provided critical insights into cardiac and vascular morphology, function, and physiology/pathophysiology in many murine models of heart disease. Furthermore, magnetic resonance spectroscopy (MRS) has allowed the nondestructive study of myocardial metabolism in both isolated hearts and in intact mice. This article reviews the current techniques and important pathophysiological insights from the application of MRI/MRS technology to murine models of cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)H633-H648
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume304
Issue number5
DOIs
StatePublished - 2013

Keywords

  • Cardiovascular
  • Magnetic resonance imaging
  • Magnetic resonance spectroscopy
  • Ventricle

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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