Magnetic resonance image example-based contrast synthesis

Snehashis Roy, Aaron Carass, Jerry L. Prince

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


The performance of image analysis algorithms applied to magnetic resonance images is strongly influenced by the pulse sequences used to acquire the images. Algorithms are typically optimized for a targeted tissue contrast obtained from a particular implementation of a pulse sequence on a specific scanner. There are many practical situations, including multi-institution trials, rapid emergency scans, and scientific use of historical data, where the images are not acquired according to an optimal protocol or the desired tissue contrast is entirely missing. This paper introduces an image restoration technique that recovers images with both the desired tissue contrast and a normalized intensity profile. This is done using patches in the acquired images and an atlas containing patches of the acquired and desired tissue contrasts. The method is an example-based approach relying on sparse reconstruction from image patches. Its performance in demonstrated using several examples, including image intensity normalization, missing tissue contrast recovery, automatic segmentation, and multimodal registration. These examples demonstrate potential practical uses and also illustrate limitations of our approach.

Original languageEnglish (US)
Article number6600832
Pages (from-to)2348-2363
Number of pages16
JournalIEEE transactions on medical imaging
Issue number12
StatePublished - Dec 2013


  • Image restoration
  • Magnetic resonance imaging (MRI)
  • Neuroimaging
  • Sparse reconstruction

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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