Magnetic resonance diffusion/perfusion phantom experiments

C. H. Lorenz, D. R. Pickens, D. B. Puffer, R. R. Price

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, several models for determining microcirculatory parameters using magnetic resonance imaging have been proposed. These include the intravoxel incoherent motion (IVIM) model, the intravoxel coherent motion (IVCM) model, and various tracer models. In order to evaluate these models before extension into physiological systems, phantom studies were used to assess model assumptions, measurement uncertainties, and sensitivity to changes in perfusion. Emphasis is placed on the IVIM model, but the techniques discussed could be extended to evaluation of other models as well. An overview of considerations in pulse sequence development, phantom design, and data interpretation is presented for a variety of phantoms ranging in complexity from stationary volumes of fluid and mechanically pumped phantoms to isolated animal kidneys and finally to an in vivo animal model.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalMagnetic Resonance in Medicine
Volume19
Issue number2
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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