Magnetic nanoparticles-based acoustical detection and hyperthermic treatment of cancer, in vitro and in vivo studies

Asaf Shoval, Michal Tepper, Jenny Tikochkiy, Leah Ben Gur, Gil Markovich, Yona Keisari, Israel Gannot

Research output: Contribution to journalArticle

Abstract

This paper describes a minimally invasive method for detection and growth inhibition of tumors that utilizes the unique properties of super paramagnetic nanoparticles. To demonstrate the feasibility of this method, dimercaptosuccinic acid-coated magnetite nanoparticles were successfully fabricated and used. Those nanoparticles were simultaneously used for magnetoacoustic detection of tumors and for specific hyperthermia treatment in C57BL/J mice injected with Lewis lung carcinoma cells. The in vivo acoustic signal attributed to the nanoparticles was 4.4 dB, while the single session hyperthermia treatment caused a reduction of 50% in tumor growing rate. In addition, a thermography-based method was applied to monitor the efficacy of the hyperthermia treatment. The presented method has the potential to revolutionize current cancer treatment by enabling diagnosis and treatment under real-time feedback in one session.

Original languageEnglish (US)
Article number036007
JournalJournal of Nanophotonics
Volume10
Issue number3
DOIs
StatePublished - Jul 1 2016

Keywords

  • cancer
  • hyperthermia therapy
  • magnetic nanoparticles
  • thermography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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