Magnetic nanoparticle heating efficiency reveals magneto-structural differences when characterized with wide ranging and high amplitude alternating magnetic fields

David E. Bordelon, Christine Cornejo, Cordula Grttner, Fritz Westphal, Theodore DeWeese, Robert Ivkov

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Abstract

Magnetic nanoparticles can create heat that can be exploited to treat cancer when they are exposed to alternating magnetic fields (AMF). At a fixed frequency, the particle heating efficiency or specific power loss (SPL) depends upon the magnitude of the AMF. We characterized the amplitude-dependent SPL of three commercial dextran-iron oxide nanoparticle suspensions through saturation to 94 kA/m with a calorimeter comprising a solenoid coil that generates a uniform field to 100 kA/m at ∼150 kHz. We also describe a novel method to empirically determine the appropriate range of the heating curve from which the SPL is then calculated. These results agree with SPL values calculated from the phenomenological Box-Lucas equation. We note that the amplitude-dependent SPL among the samples was markedly different, indicating significant magneto-structural variation not anticipated by current models.

Original languageEnglish (US)
Article number124904
JournalJournal of Applied Physics
Volume109
Issue number12
DOIs
StatePublished - Jun 15 2011

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ASJC Scopus subject areas

  • Physics and Astronomy(all)

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