Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans

Keon Mahmoudi, Alexandros Bouras, Dominique Bozec, Robert Ivkov, Constantinos Hadjipanayis

Research output: Contribution to journalReview articlepeer-review

Abstract

Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer treatment have been studied for decades. Techniques used to achieve a localised hyperthermic effect include radiofrequency, ultrasound, microwave, laser and magnetic nanoparticles (MNPs). The use of MNPs for therapeutic hyperthermia generation is known as magnetic hyperthermia therapy (MHT) and was first attempted as a cancer therapy in 1957. However, despite more recent advancements, MHT has still not become part of the standard of care for cancer treatment. Certain challenges, such as accurate thermometry within the tumour mass and precise tumour heating, preclude its widespread application as a treatment modality for cancer. MHT is especially attractive for the treatment of glioblastoma (GBM), the most common and aggressive primary brain cancer in adults, which has no cure. In this review, the application of MHT as a therapeutic modality for GBM will be discussed. Its therapeutic efficacy, technical details, and major experimental and clinical findings will be reviewed and analysed. Finally, current limitations, areas of improvement, and future directions will be discussed in depth.

Original languageEnglish (US)
Pages (from-to)1316-1328
Number of pages13
JournalInternational Journal of Hyperthermia
Volume34
Issue number8
DOIs
StatePublished - Nov 17 2018

Keywords

  • Magnetic hyperthermia therapy
  • alternating magnetic field
  • convection enhanced delivery
  • glioblastoma
  • magnetic nanoparticles

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

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