Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain

Jens H. Jensen, Kamila Szulc, Caixia Hu, Anita Ramani, Hanzhang Lu, Liang Xuan, Maria F. Falangola, Ramesh Chandra, Edmond A. Knopp, John Schenck, Earl A. Zimmerman, Joseph A. Helpern

Research output: Contribution to journalArticle

Abstract

The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.

Original languageEnglish (US)
Pages (from-to)481-485
Number of pages5
JournalMagnetic Resonance in Medicine
Volume61
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Fingerprint

Magnetic Fields
Iron
Brain
Globus Pallidus
Basal Ganglia
Thalamus
Heme
Healthy Volunteers
Familial apoceruloplasmin deficiency

Keywords

  • Aceruloplasminemia
  • Brain
  • Iron
  • Magnetic field correlation
  • Magnetic field inhomogeneities
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. / Jensen, Jens H.; Szulc, Kamila; Hu, Caixia; Ramani, Anita; Lu, Hanzhang; Xuan, Liang; Falangola, Maria F.; Chandra, Ramesh; Knopp, Edmond A.; Schenck, John; Zimmerman, Earl A.; Helpern, Joseph A.

In: Magnetic Resonance in Medicine, Vol. 61, No. 2, 02.2009, p. 481-485.

Research output: Contribution to journalArticle

Jensen, JH, Szulc, K, Hu, C, Ramani, A, Lu, H, Xuan, L, Falangola, MF, Chandra, R, Knopp, EA, Schenck, J, Zimmerman, EA & Helpern, JA 2009, 'Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain', Magnetic Resonance in Medicine, vol. 61, no. 2, pp. 481-485. https://doi.org/10.1002/mrm.21823
Jensen, Jens H. ; Szulc, Kamila ; Hu, Caixia ; Ramani, Anita ; Lu, Hanzhang ; Xuan, Liang ; Falangola, Maria F. ; Chandra, Ramesh ; Knopp, Edmond A. ; Schenck, John ; Zimmerman, Earl A. ; Helpern, Joseph A. / Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. In: Magnetic Resonance in Medicine. 2009 ; Vol. 61, No. 2. pp. 481-485.
@article{efe2c4e4766b4691990cdb05a930cc59,
title = "Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain",
abstract = "The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.",
keywords = "Aceruloplasminemia, Brain, Iron, Magnetic field correlation, Magnetic field inhomogeneities, MRI",
author = "Jensen, {Jens H.} and Kamila Szulc and Caixia Hu and Anita Ramani and Hanzhang Lu and Liang Xuan and Falangola, {Maria F.} and Ramesh Chandra and Knopp, {Edmond A.} and John Schenck and Zimmerman, {Earl A.} and Helpern, {Joseph A.}",
year = "2009",
month = "2",
doi = "10.1002/mrm.21823",
language = "English (US)",
volume = "61",
pages = "481--485",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain

AU - Jensen, Jens H.

AU - Szulc, Kamila

AU - Hu, Caixia

AU - Ramani, Anita

AU - Lu, Hanzhang

AU - Xuan, Liang

AU - Falangola, Maria F.

AU - Chandra, Ramesh

AU - Knopp, Edmond A.

AU - Schenck, John

AU - Zimmerman, Earl A.

AU - Helpern, Joseph A.

PY - 2009/2

Y1 - 2009/2

N2 - The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.

AB - The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by non- heme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease.

KW - Aceruloplasminemia

KW - Brain

KW - Iron

KW - Magnetic field correlation

KW - Magnetic field inhomogeneities

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=60549108590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549108590&partnerID=8YFLogxK

U2 - 10.1002/mrm.21823

DO - 10.1002/mrm.21823

M3 - Article

VL - 61

SP - 481

EP - 485

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -