Magnesium plus mexiletine inhibit energy usage and protect retinas against ischemia

Kenneth I. Maynard, Alfredo Quiñones-Hinojosa, Christopher S. Ogilvy

Research output: Contribution to journalArticle

Abstract

We determined whether exogenous Mg2+ and/or mexiletine (Mex), which are reported to be neuroprotective agents, reduced neuronal energy requirements and protected against ischemia, using isolated rabbit retinas. Under non-ischemic conditions, Mex (300 μM) and the combination of Mg2+ (1 mM) plus Mex (300 μM) significantly reduced glucose utilization, by 19% and 31%, respectively. The combination of Mg2+ plus Mex, but not either agent alone, significantly reduced lactate production (by 18%; p < 0.05). When added during 2 h of ischemia (simulated by the reduction of oxygen from 95% to 15% and of glucose from 6 mM to 1 mM), Mg2+ plus Mex improved the recovery of glucose utilization (p < 0.01), lactate production (p < 0.05) and neuronal function (p < 0.05) for 3 h following return to control (post- ischemia/recovery) conditions. Thus reducing energy demands by blocking functions during temporary ischemia, protects neurons from irreversible functional damage.

Original languageEnglish (US)
Pages (from-to)4141-4144
Number of pages4
JournalNeuroreport
Volume9
Issue number18
DOIs
StatePublished - Dec 21 1998

Keywords

  • Energy metabolism
  • Ischemia
  • Metabolic inhibition
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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