Magnesium deficiency prolongs myocardial stunning in an open-chest swine model

William R. Herzog; Dan Atar; I. Tong Mak; David Alyono; Christopher MacCord; William B. Weglicki

doi:10.1016/0167-5273(94)90176-7

Magnesium deficiency prolongs myocardial stunning in an open-chest swine model

William R. Herzog, Dan Atar, I. Tong Mak, David Alyono, Christopher MacCord, William B. Weglicki

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 ± 3.1 min in the control group to 43.8 ± 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.

Original language	English (US)
Pages (from-to)	105-115
Number of pages	11
Journal	International Journal of Cardiology
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/0167-5273(94)90176-7
State	Published - Dec 1994
Externally published	Yes

Keywords

Contractility
Ischemia
Magnesium
Reperfusion
Stunning

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0167-5273(94)90176-7

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title = "Magnesium deficiency prolongs myocardial stunning in an open-chest swine model",

abstract = "The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 ± 3.1 min in the control group to 43.8 ± 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.",

keywords = "Contractility, Ischemia, Magnesium, Reperfusion, Stunning",

author = "Herzog, {William R.} and Dan Atar and {Tong Mak}, I. and David Alyono and Christopher MacCord and Weglicki, {William B.}",

note = "Funding Information: This work wass upportedb y a facultys eedf und of theU niversityo f MarylandS choolo f Medicine, grant No. 0239051a0n d USPHS grant HL-ROl-49232( WBW). Dan Atar is a recipiento f a travel grantf rom the DanishH eart Foundation.T he ex-cellentt echnicaal ssistancoef Helen Scotti s highly appreciated.",

year = "1994",

month = dec,

doi = "10.1016/0167-5273(94)90176-7",

language = "English (US)",

volume = "47",

pages = "105--115",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Magnesium deficiency prolongs myocardial stunning in an open-chest swine model

AU - Herzog, William R.

AU - Atar, Dan

AU - Tong Mak, I.

AU - Alyono, David

AU - MacCord, Christopher

AU - Weglicki, William B.

N1 - Funding Information: This work wass upportedb y a facultys eedf und of theU niversityo f MarylandS choolo f Medicine, grant No. 0239051a0n d USPHS grant HL-ROl-49232( WBW). Dan Atar is a recipiento f a travel grantf rom the DanishH eart Foundation.T he ex-cellentt echnicaal ssistancoef Helen Scotti s highly appreciated.

PY - 1994/12

Y1 - 1994/12

N2 - The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 ± 3.1 min in the control group to 43.8 ± 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.

AB - The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 ± 3.1 min in the control group to 43.8 ± 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.

KW - Contractility

KW - Ischemia

KW - Magnesium

KW - Reperfusion

KW - Stunning

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JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

Magnesium deficiency prolongs myocardial stunning in an open-chest swine model

Abstract

Keywords

ASJC Scopus subject areas

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