Magnesium deficiency prolongs myocardial stunning in an open-chest swine model

William R. Herzog, Dan Atar, I. Tong Mak, David Alyono, Christopher MacCord, William B. Weglicki

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 ± 3.1 min in the control group to 43.8 ± 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalInternational Journal of Cardiology
Volume47
Issue number2
DOIs
StatePublished - Dec 1994

Keywords

  • Contractility
  • Ischemia
  • Magnesium
  • Reperfusion
  • Stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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