Magnesium deficiency prolongs myocardial stunning in an open-chest swine model

William Raymond Herzog, Dan Atar, I. Tong Mak, David Alyono, Christopher MacCord, William B. Weglicki

Research output: Contribution to journalArticle

Abstract

The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 ± 3.1 min in the control group to 43.8 ± 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalInternational Journal of Cardiology
Volume47
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

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Magnesium Deficiency
Myocardial Stunning
Swine
Thorax
Magnesium
Diet
Glutathione
Coronary Vessels
Control Groups
Serum

Keywords

  • Contractility
  • Ischemia
  • Magnesium
  • Reperfusion
  • Stunning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Herzog, W. R., Atar, D., Tong Mak, I., Alyono, D., MacCord, C., & Weglicki, W. B. (1994). Magnesium deficiency prolongs myocardial stunning in an open-chest swine model. International Journal of Cardiology, 47(2), 105-115. https://doi.org/10.1016/0167-5273(94)90176-7

Magnesium deficiency prolongs myocardial stunning in an open-chest swine model. / Herzog, William Raymond; Atar, Dan; Tong Mak, I.; Alyono, David; MacCord, Christopher; Weglicki, William B.

In: International Journal of Cardiology, Vol. 47, No. 2, 1994, p. 105-115.

Research output: Contribution to journalArticle

Herzog, WR, Atar, D, Tong Mak, I, Alyono, D, MacCord, C & Weglicki, WB 1994, 'Magnesium deficiency prolongs myocardial stunning in an open-chest swine model', International Journal of Cardiology, vol. 47, no. 2, pp. 105-115. https://doi.org/10.1016/0167-5273(94)90176-7
Herzog, William Raymond ; Atar, Dan ; Tong Mak, I. ; Alyono, David ; MacCord, Christopher ; Weglicki, William B. / Magnesium deficiency prolongs myocardial stunning in an open-chest swine model. In: International Journal of Cardiology. 1994 ; Vol. 47, No. 2. pp. 105-115.
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