TY - JOUR
T1 - Magnesium and anabolic hormones in older men
AU - Maggio, M.
AU - Ceda, G. P.
AU - Lauretani, F.
AU - Cattabiani, C.
AU - Avantaggiato, E.
AU - Morganti, S.
AU - Ablondi, F.
AU - Bandinelli, S.
AU - Dominguez, L. J.
AU - Barbagallo, M.
AU - Paolisso, G.
AU - Semba, R. D.
AU - Ferrucci, L.
PY - 2011/12
Y1 - 2011/12
N2 - Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18±6.43 (years±SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β±SE, 34.9±10.3; p=0.001) and with total IGF-1 (β±SE, 15.9±4.8; p=0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β±SE, 48.72±12.61; p=0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β±SE, 16.43±4.90; p=0.001) and remained significant after adjusting for total testosterone (β±SE, 14.4±4.9; p=0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.
AB - Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18±6.43 (years±SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β±SE, 34.9±10.3; p=0.001) and with total IGF-1 (β±SE, 15.9±4.8; p=0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β±SE, 48.72±12.61; p=0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β±SE, 16.43±4.90; p=0.001) and remained significant after adjusting for total testosterone (β±SE, 14.4±4.9; p=0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.
KW - Anabolic hormones
KW - Magnesium
KW - Older men
UR - http://www.scopus.com/inward/record.url?scp=79957463048&partnerID=8YFLogxK
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U2 - 10.1111/j.1365-2605.2011.01193.x
DO - 10.1111/j.1365-2605.2011.01193.x
M3 - Article
C2 - 21675994
AN - SCOPUS:79957463048
SN - 0105-6263
VL - 34
SP - e594-e600
JO - International Journal of Andrology
JF - International Journal of Andrology
IS - 6 PART 2
ER -