Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema

Roberto Gallego-Pinazo, Ana Marina Suelves-Cogollos, Rosa Dolz-Marco, J Fernando Arevalo, Salvador García-Delpech, J. Luis Mullor, Manuel Díaz-Llopis

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema. Methods: This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser pho- tocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment. Results: Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 ± 0.2 to 0.37 ± 0.2 (P, 0.001), and decreased mean central macular thickness from 397.25 ± 139.1 to 333.50 ± 105.7 μm (P<0.001) and retinal volume from 12.61 ± 1.6 to 10.94 ± 1.4 mm3 (P<0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 ± 0.2 to 0.33 ± 0.2 logMAR (P<0.001), and decreased mean central macular thickness from 425.90 ± 149.6 to 353.4 ± 140 μm (P<0.001) and retinal volume from 12.38 ± 2.1 to 11.53 ± 1.1 mm3 (P<0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582). Conclusion: The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
JournalClinical Ophthalmology
Volume5
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Macular Edema
Fluorescein Angiography
Light Coagulation
Optical Coherence Tomography
Lasers
Visual Acuity
Therapeutics

Keywords

  • Diabetic macular edema
  • Fluorescein angiography
  • Macular laser photocoagulation
  • Spectral-domain optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Gallego-Pinazo, R., Suelves-Cogollos, A. M., Dolz-Marco, R., Arevalo, J. F., García-Delpech, S., Luis Mullor, J., & Díaz-Llopis, M. (2011). Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema. Clinical Ophthalmology, 5(1), 613-617. https://doi.org/10.2147/OPTH.S16833

Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema. / Gallego-Pinazo, Roberto; Suelves-Cogollos, Ana Marina; Dolz-Marco, Rosa; Arevalo, J Fernando; García-Delpech, Salvador; Luis Mullor, J.; Díaz-Llopis, Manuel.

In: Clinical Ophthalmology, Vol. 5, No. 1, 2011, p. 613-617.

Research output: Contribution to journalArticle

Gallego-Pinazo, R, Suelves-Cogollos, AM, Dolz-Marco, R, Arevalo, JF, García-Delpech, S, Luis Mullor, J & Díaz-Llopis, M 2011, 'Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema', Clinical Ophthalmology, vol. 5, no. 1, pp. 613-617. https://doi.org/10.2147/OPTH.S16833
Gallego-Pinazo, Roberto ; Suelves-Cogollos, Ana Marina ; Dolz-Marco, Rosa ; Arevalo, J Fernando ; García-Delpech, Salvador ; Luis Mullor, J. ; Díaz-Llopis, Manuel. / Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema. In: Clinical Ophthalmology. 2011 ; Vol. 5, No. 1. pp. 613-617.
@article{d2c50a35724541309b23d1f1849e40f6,
title = "Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema",
abstract = "Background: The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema. Methods: This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser pho- tocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment. Results: Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 ± 0.2 to 0.37 ± 0.2 (P, 0.001), and decreased mean central macular thickness from 397.25 ± 139.1 to 333.50 ± 105.7 μm (P<0.001) and retinal volume from 12.61 ± 1.6 to 10.94 ± 1.4 mm3 (P<0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 ± 0.2 to 0.33 ± 0.2 logMAR (P<0.001), and decreased mean central macular thickness from 425.90 ± 149.6 to 353.4 ± 140 μm (P<0.001) and retinal volume from 12.38 ± 2.1 to 11.53 ± 1.1 mm3 (P<0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582). Conclusion: The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.",
keywords = "Diabetic macular edema, Fluorescein angiography, Macular laser photocoagulation, Spectral-domain optical coherence tomography",
author = "Roberto Gallego-Pinazo and Suelves-Cogollos, {Ana Marina} and Rosa Dolz-Marco and Arevalo, {J Fernando} and Salvador Garc{\'i}a-Delpech and {Luis Mullor}, J. and Manuel D{\'i}az-Llopis",
year = "2011",
doi = "10.2147/OPTH.S16833",
language = "English (US)",
volume = "5",
pages = "613--617",
journal = "Clinical Ophthalmology",
issn = "1177-5467",
publisher = "Dove Medical Press Ltd.",
number = "1",

}

TY - JOUR

T1 - Macular laser photocoagulation guided by spectral-domain optical coherence tomography versus fluorescein angiography for diabetic macular edema

AU - Gallego-Pinazo, Roberto

AU - Suelves-Cogollos, Ana Marina

AU - Dolz-Marco, Rosa

AU - Arevalo, J Fernando

AU - García-Delpech, Salvador

AU - Luis Mullor, J.

AU - Díaz-Llopis, Manuel

PY - 2011

Y1 - 2011

N2 - Background: The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema. Methods: This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser pho- tocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment. Results: Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 ± 0.2 to 0.37 ± 0.2 (P, 0.001), and decreased mean central macular thickness from 397.25 ± 139.1 to 333.50 ± 105.7 μm (P<0.001) and retinal volume from 12.61 ± 1.6 to 10.94 ± 1.4 mm3 (P<0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 ± 0.2 to 0.33 ± 0.2 logMAR (P<0.001), and decreased mean central macular thickness from 425.90 ± 149.6 to 353.4 ± 140 μm (P<0.001) and retinal volume from 12.38 ± 2.1 to 11.53 ± 1.1 mm3 (P<0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582). Conclusion: The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.

AB - Background: The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema. Methods: This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser pho- tocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment. Results: Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 ± 0.2 to 0.37 ± 0.2 (P, 0.001), and decreased mean central macular thickness from 397.25 ± 139.1 to 333.50 ± 105.7 μm (P<0.001) and retinal volume from 12.61 ± 1.6 to 10.94 ± 1.4 mm3 (P<0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 ± 0.2 to 0.33 ± 0.2 logMAR (P<0.001), and decreased mean central macular thickness from 425.90 ± 149.6 to 353.4 ± 140 μm (P<0.001) and retinal volume from 12.38 ± 2.1 to 11.53 ± 1.1 mm3 (P<0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582). Conclusion: The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.

KW - Diabetic macular edema

KW - Fluorescein angiography

KW - Macular laser photocoagulation

KW - Spectral-domain optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=79957472466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957472466&partnerID=8YFLogxK

U2 - 10.2147/OPTH.S16833

DO - 10.2147/OPTH.S16833

M3 - Article

VL - 5

SP - 613

EP - 617

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

SN - 1177-5467

IS - 1

ER -