TY - JOUR
T1 - Macular full-thickness and lamellar holes in association with type 2 idiopathic macular telangiectasia
AU - Charbel Issa, P.
AU - Scholl, H. P.N.
AU - Gaudric, A.
AU - Massin, P.
AU - Kreiger, A. E.
AU - Schwartz, S.
AU - Holz, F. G.
N1 - Funding Information:
This study was supported by The Lowy Medical Research Institute (The Macular Telangiectasia Project; http://www.mactelresearch.org), DFG Heisenberg fellowship SCHO 734/2-1; EU FP6, Integrated Project ‘EVI-GENORET’ (LSHG-CT-2005-512036).
PY - 2009/2
Y1 - 2009/2
N2 - Purpose: To describe patients with full-thickness macular holes (FTMHs) and lamellar macular holes (LMHs) in association with type 2 idiopathic macular telangiectasia (type 2 IMT). Methods: Six patients with either FTMH or LMH and type 2 IMT were evaluated by means of optical coherence tomography (OCT) imaging, funduscopy, and fluorescein angiography. Results: The age of the examined patients ranged from 57 to 70 years (mean 62.5±5.2), and best-corrected visual acuity of the affected eyes ranged from 20/50 to 20/200 (mean 20/100). All eyes showed macular abnormalities typical for nonproliferative type 2 IMT except for one eye with a proliferative disease stage. Three patients had an FTMH, one presenting with bilateral FTMH, and three had an LMH on OCT. In all cases of FTMH, the macular holes did not have elevated margins. Surgery was performed in two patients with a FTHM without subsequent functional improvement. Conclusions: The altered foveal anatomy with progressive atrophic changes within the neurosensory retina in type 2 IMT may predispose to the development of FTMH and LMH. Type 2 IMT should be considered in the differential diagnosis in patients presenting with macular holes. The association between the two may reflect alternative pathogenetic mechanisms in the development of macular holes.
AB - Purpose: To describe patients with full-thickness macular holes (FTMHs) and lamellar macular holes (LMHs) in association with type 2 idiopathic macular telangiectasia (type 2 IMT). Methods: Six patients with either FTMH or LMH and type 2 IMT were evaluated by means of optical coherence tomography (OCT) imaging, funduscopy, and fluorescein angiography. Results: The age of the examined patients ranged from 57 to 70 years (mean 62.5±5.2), and best-corrected visual acuity of the affected eyes ranged from 20/50 to 20/200 (mean 20/100). All eyes showed macular abnormalities typical for nonproliferative type 2 IMT except for one eye with a proliferative disease stage. Three patients had an FTMH, one presenting with bilateral FTMH, and three had an LMH on OCT. In all cases of FTMH, the macular holes did not have elevated margins. Surgery was performed in two patients with a FTHM without subsequent functional improvement. Conclusions: The altered foveal anatomy with progressive atrophic changes within the neurosensory retina in type 2 IMT may predispose to the development of FTMH and LMH. Type 2 IMT should be considered in the differential diagnosis in patients presenting with macular holes. The association between the two may reflect alternative pathogenetic mechanisms in the development of macular holes.
KW - Full-thickness macular hole
KW - Idiopathic macular telangiectasia
KW - Idiopathic parafoveolar telangiectasis
KW - Lamellar macular hole
KW - Optical coherence tomography
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U2 - 10.1038/sj.eye.6703003
DO - 10.1038/sj.eye.6703003
M3 - Article
C2 - 18259211
AN - SCOPUS:60149095120
SN - 0950-222X
VL - 23
SP - 435
EP - 441
JO - Transactions of the Ophthalmological Societies of the United Kingdom
JF - Transactions of the Ophthalmological Societies of the United Kingdom
IS - 2
ER -