TY - JOUR
T1 - Macular features on spectral-domain optical coherence tomography imaging associated with visual acuity in coats’ disease
AU - Ong, Sally S.
AU - Mruthyunjaya, Prithvi
AU - Stinnett, Sandra
AU - Vajzovic, Lejla
AU - Toth, Cynthia A.
N1 - Funding Information:
Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, Honolulu, Hawaii, United States, April 29–May 3, 2018. The authors thank Katrina P. Winter, BS, Du Tran-Viet, BS, and Vincent Tai, MS, for assistance with image acquisition and analysis. Supported by The International Retinal Research Foundation, The Hartwell Foundation, The Andrew Family Charitable Foundation, National Institutes of Health (NIH) Grants 1RO1 EY025009 and UL1 RR024128 (Pilot project grant) from Duke Translational Research Institute and NIH Roadmap for Medical Research. The writing and content of the paper are solely the responsibility of the authors and do not necessarily represent the official view of NIH. The sponsors or funding organizations had no role in the design or conduct of this research.
Publisher Copyright:
© 2018 The Authors.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - PURPOSE. To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats’ disease. METHODS. Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 2016 were reviewed for SD-OCT features. Central subfield (CSF) SD-OCT findings were analyzed relative to VA (logarithm of the minimum angle of resolution) at baseline and final visit (when follow-up ≥ 6 months) and across visits. RESULTS. Mean VA ± standard deviation at baseline (37 eyes) was 0.92 ± 0.82. SD-OCT features associated with worse VA included, for treatment-naïve eyes (n = 21), outer retinal atrophy (ORA) (1.18 ± 0.34 with versus 0.20 ± 0.30 without, P = 0.005), subretinal fluid (SRF) (1.80 ± 0.63 vs. 0.63 ± 0.50, P = 0.008), bright hyperreflectivities (1.23 ± 0.68 vs. 0.52 ± 0.53, P = 0.02), thicker foveal subretinal space (r2 = 0.32, P = 0.01), and CSF (r2 = 0.39, P = 0.007); and for previously treated eyes (n = 16), a compact hyperreflective structure (1.60 ± 0.88 vs. 0.56 ± 0.64, P = 0.02) and ORA (1.34 ± 0.86 vs. 0.30 ± 0.44, P = 0.01). At final follow-up (n = 22), mean VA was 0.81 ± 0.83. Eyes with final VA <20/200 (n = 6, vs. >20/60, n = 11) more commonly had a compact hyperreflective structure and ORA at baseline and final visit (P < 0.05). Mean change in VA from baseline (n = 20) was 0.20 ± 0.59. Mean improvement in VA (range, 0.525 to 1.127) occurred in eyes with baseline SRF (P = 0.02) and bright hyperreflectivities (P = 0.03). Changes in thickness that correlated with change in VA included those for the foveal subretinal space (r2 = 0.52, P < 0.001) and CSF (r2 = 0.26, P = 0.045). CONCLUSIONS. A compact hyperreflective structure (fibrosis) and ORA were associated with poor final VA while SRF, bright hyperreflectivities (exudation), and foveal subretinal thickness were associated with VA improvement post treatment.
AB - PURPOSE. To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats’ disease. METHODS. Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 2016 were reviewed for SD-OCT features. Central subfield (CSF) SD-OCT findings were analyzed relative to VA (logarithm of the minimum angle of resolution) at baseline and final visit (when follow-up ≥ 6 months) and across visits. RESULTS. Mean VA ± standard deviation at baseline (37 eyes) was 0.92 ± 0.82. SD-OCT features associated with worse VA included, for treatment-naïve eyes (n = 21), outer retinal atrophy (ORA) (1.18 ± 0.34 with versus 0.20 ± 0.30 without, P = 0.005), subretinal fluid (SRF) (1.80 ± 0.63 vs. 0.63 ± 0.50, P = 0.008), bright hyperreflectivities (1.23 ± 0.68 vs. 0.52 ± 0.53, P = 0.02), thicker foveal subretinal space (r2 = 0.32, P = 0.01), and CSF (r2 = 0.39, P = 0.007); and for previously treated eyes (n = 16), a compact hyperreflective structure (1.60 ± 0.88 vs. 0.56 ± 0.64, P = 0.02) and ORA (1.34 ± 0.86 vs. 0.30 ± 0.44, P = 0.01). At final follow-up (n = 22), mean VA was 0.81 ± 0.83. Eyes with final VA <20/200 (n = 6, vs. >20/60, n = 11) more commonly had a compact hyperreflective structure and ORA at baseline and final visit (P < 0.05). Mean change in VA from baseline (n = 20) was 0.20 ± 0.59. Mean improvement in VA (range, 0.525 to 1.127) occurred in eyes with baseline SRF (P = 0.02) and bright hyperreflectivities (P = 0.03). Changes in thickness that correlated with change in VA included those for the foveal subretinal space (r2 = 0.52, P < 0.001) and CSF (r2 = 0.26, P = 0.045). CONCLUSIONS. A compact hyperreflective structure (fibrosis) and ORA were associated with poor final VA while SRF, bright hyperreflectivities (exudation), and foveal subretinal thickness were associated with VA improvement post treatment.
KW - Coats’ disease
KW - Pediatric retina
KW - Pediatric retinal imaging
KW - SD-OCT
KW - Spectral-domain optical coherence tomography
KW - VA
KW - Visual acuity
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U2 - 10.1167/iovs.18-24109
DO - 10.1167/iovs.18-24109
M3 - Article
C2 - 30025132
AN - SCOPUS:85061946150
VL - 59
SP - 3161
EP - 3174
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 7
ER -