Macroscopic type is a prognostic factor for recurrence-free survival after resection of gastric GIST

Hiroshi Miyamoto, Chikara Kunisaki, Yuichi Otsuka, Masazumi Takahashi, Ryo Takagawa, Koichiro Misuta, Kunio Kameda, Hirochika Makino, Goro Matsuda, Naotaka Yamaguchi, Noriyuki Kamiya, Takashi Murakami, Satoshi Morita, Hirotoshi Akiyama, Itaru Endo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Accurate evaluation of the biological behavior of Gastrointestinal stromal tumor and careful selection of patients with a high risk for tumor recurrence are necessary. In the present study, we analyzed prognostic factors in patients with GIST. Patients and Methods: A total of 214 patients who had undergone curative resection of a localized primary gastric GIST without adjuvant therapy were enrolled in this retrospective study. Prognostic factors were analyzed. The growth pattern was classified as intramural, endoluminal, exoluminal, or mixed- type. Results: On univariate and multivariate analyses, recurrence was predicted by exoluminal or mixed-type (hazard ratio [HR]=3.7, p=0.043), tumor size of >3.5 cm (HR=7.1, p=0.01), and mitotic rate of >5/50 high-power fields (HR=7.9, p

Original languageEnglish (US)
Pages (from-to)4267-4274
Number of pages8
JournalAnticancer Research
Volume34
Issue number8
StatePublished - Aug 1 2014
Externally publishedYes

Keywords

  • Gastrointestinal stromal tumor
  • GIST
  • Prognosis
  • Risk of recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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