Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34

G. R. Cutting, H. H. Kazazian, S. E. Antonarakis, P. D. Killen, Y. Yamada, C. A. Francomano

Research output: Contribution to journalArticle

Abstract

The genes for the α-1 and α-2 chains of type IV collagen (COL4A1 and COL4A2) map to the same chromosomal band (13q34) and have a high degree of nucleotide homology. We have used pulsed field gel electrophoresis and cloned COL4A1 and COL4A2 DNA fragments as molecular probes to construct a 1200-kb macrorestriction map which encompasses both genes. The two genes are located within a 340-kb region with the 3′ end of COL4A2 and the 5′ region of COL4A1 separated by at least 100 kb but not more than 160 kb. These genes, therefore, are two members of a gene cluster on chromosome 13q34.

Original languageEnglish (US)
Pages (from-to)256-263
Number of pages8
JournalGenomics
Volume3
Issue number3
DOIs
StatePublished - Oct 1988

ASJC Scopus subject areas

  • Genetics

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