Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34

G. R. Cutting; H. H. Kazazian; S. E. Antonarakis; P. D. Killen; Y. Yamada; C. A. Francomano

doi:10.1016/0888-7543(88)90086-9

Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34

G. R. Cutting, H. H. Kazazian, S. E. Antonarakis, P. D. Killen, Y. Yamada, C. A. Francomano

School of Medicine

Research output: Contribution to journal › Article › peer-review

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Abstract

The genes for the α-1 and α-2 chains of type IV collagen (COL4A1 and COL4A2) map to the same chromosomal band (13q34) and have a high degree of nucleotide homology. We have used pulsed field gel electrophoresis and cloned COL4A1 and COL4A2 DNA fragments as molecular probes to construct a 1200-kb macrorestriction map which encompasses both genes. The two genes are located within a 340-kb region with the 3′ end of COL4A2 and the 5′ region of COL4A1 separated by at least 100 kb but not more than 160 kb. These genes, therefore, are two members of a gene cluster on chromosome 13q34.

Original language	English (US)
Pages (from-to)	256-263
Number of pages	8
Journal	Genomics
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/0888-7543(88)90086-9
State	Published - Oct 1988

ASJC Scopus subject areas

Genetics

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10.1016/0888-7543(88)90086-9

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@article{c4a21f28d69e4ce2886db37ceae1dfd7,

title = "Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34",

abstract = "The genes for the α-1 and α-2 chains of type IV collagen (COL4A1 and COL4A2) map to the same chromosomal band (13q34) and have a high degree of nucleotide homology. We have used pulsed field gel electrophoresis and cloned COL4A1 and COL4A2 DNA fragments as molecular probes to construct a 1200-kb macrorestriction map which encompasses both genes. The two genes are located within a 340-kb region with the 3′ end of COL4A2 and the 5′ region of COL4A1 separated by at least 100 kb but not more than 160 kb. These genes, therefore, are two members of a gene cluster on chromosome 13q34.",

author = "Cutting, {G. R.} and Kazazian, {H. H.} and Antonarakis, {S. E.} and Killen, {P. D.} and Y. Yamada and Francomano, {C. A.}",

note = "Funding Information: The authors thank Hee Kyung Hong, Lan Le, and Laura Kasch for technical assistance and Diane Darchicourt for typing the manuscript. This work was supported by NIH Grants to H.H.K., Jr., S.E.A., and C.A.F.",

year = "1988",

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doi = "10.1016/0888-7543(88)90086-9",

language = "English (US)",

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pages = "256--263",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34

AU - Cutting, G. R.

AU - Kazazian, H. H.

AU - Antonarakis, S. E.

AU - Killen, P. D.

AU - Yamada, Y.

AU - Francomano, C. A.

N1 - Funding Information: The authors thank Hee Kyung Hong, Lan Le, and Laura Kasch for technical assistance and Diane Darchicourt for typing the manuscript. This work was supported by NIH Grants to H.H.K., Jr., S.E.A., and C.A.F.

PY - 1988/10

Y1 - 1988/10

N2 - The genes for the α-1 and α-2 chains of type IV collagen (COL4A1 and COL4A2) map to the same chromosomal band (13q34) and have a high degree of nucleotide homology. We have used pulsed field gel electrophoresis and cloned COL4A1 and COL4A2 DNA fragments as molecular probes to construct a 1200-kb macrorestriction map which encompasses both genes. The two genes are located within a 340-kb region with the 3′ end of COL4A2 and the 5′ region of COL4A1 separated by at least 100 kb but not more than 160 kb. These genes, therefore, are two members of a gene cluster on chromosome 13q34.

AB - The genes for the α-1 and α-2 chains of type IV collagen (COL4A1 and COL4A2) map to the same chromosomal band (13q34) and have a high degree of nucleotide homology. We have used pulsed field gel electrophoresis and cloned COL4A1 and COL4A2 DNA fragments as molecular probes to construct a 1200-kb macrorestriction map which encompasses both genes. The two genes are located within a 340-kb region with the 3′ end of COL4A2 and the 5′ region of COL4A1 separated by at least 100 kb but not more than 160 kb. These genes, therefore, are two members of a gene cluster on chromosome 13q34.

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JO - Genomics

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Macrorestriction mapping of COL4A1 and COL4A2 collagen genes on human chromosome 13q34

Abstract

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