Macrophages participate in IL-17-mediated inflammation

Jobert G. Barin, G. Christian Baldeviano, Monica V. Talor, Lei Wu, Sufey Ong, Farhan Quader, Ping Chen, Dongfeng Zheng, Patrizio Caturegli, Noel R. Rose, Daniela Čiháková

Research output: Contribution to journalArticlepeer-review


The involvement of macrophages (MΦs) in Th17-cell responses is still poorly understood. While neutrophils are thought to be the predominant effector of Th17-cell responses, IL-17 is also known to induce myelotropic chemokines and growth factors. Other T-cell-derived cytokines induce non-classical functions, suggesting that IL-17 sigxnaling may similarly elicit unique MΦ functions. Here, we characterized the expression of subunits of the IL-17 receptor on primary murine MΦs from different anatomical compartments. The greatest expression of IL-17 receptors was observed on mucosal Ly6C hi "inflammatory" MΦs. We further observed upregulation of IL-17 receptors in vitro on bone marrow-derived macrophages (BMMΦs) in response to peptidoglycan or CpG oligonucleotide stimuli, and in vivo, upon CFA administration. Macrophages expressing IL-17 receptors were observed infiltrating the hearts of mice with myocarditis, and genetic ablation of IL-17RA altered MΦ recruitment. Treating primary MΦs from a wide variety of different anatomic sources (as well as cell lines) with IL-17A induced the production of unique profiles of cytokines and chemokines, including GM-CSF, IL-3, IL-9, CCL4/MIP-1β and CCL5/RANTES. IL-17A also induced production of IL-12p70; IL-17-signaling-deficient MΦs elicited diminished IFN-γ production by responding DO11.10 CD4 + T cells when used as APCs. These data indicate that MΦs from different anatomic locations direct IL-17-mediated responses.

Original languageEnglish (US)
Pages (from-to)726-736
Number of pages11
JournalEuropean Journal of Immunology
Issue number3
StatePublished - Mar 2012


  • Interleukin-17
  • K'xFC;pffer cell
  • MF
  • Microglia
  • Monocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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