Macrophage-activating cytokines in human immununodeficiency virus type 1-infected and -uninfected patients with pulmonary tuberculosis

H. Mayanja-Kizza, J. L. Johnson, C. S. Hirsch, P. Peters, K. Surewicz, M. Wu, G. Nalugwa, F. Mubiru, H. Luzze, A. Wajja, H. Aung, J. J. Ellner, C. Whalen, Z. Toossi

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Tuberculosis (TB) is the most common opportunistic infection in human immunodeficiency virus type 1 (HIV-1)-infected patients globally and occurs throughout the course of HIV-1 disease. Here the production of interferon (IFN)-γ and tumor necrosis factor (TNF)-α by peripheral blood mononuclear cells (PBMC) of HIV-1-infected versus -uninfected patients with newly diagnosed pulmonary TB (PTB) was compared. Findings were correlated with cytokine profiles, clinical presentation, and expression of inducible nitric oxide (iNOS). Most HIV-1/PTB patients with a CD4 cell count of 200-500 cells/μL had high IFN-γ production and radiographic evidence of atypical PTB. Low IFN-α production and radiographic evidence of reactivated PTB characterized both HIV-1/PTB patients with a CD4 cell count ≥500 cells/μL and HIV-1-uninfected patients. TNF-α levels were similar in all HIV-1/PTB patients, regardless of CD4 cell count. Induction of iNOS in PBMC was low and was associated with low IFN-α production. These data underscore the potential pathogenic role of macrophage-activating cytokines in TB in HIV-1-infected patients.

Original languageEnglish (US)
Pages (from-to)1805-1809
Number of pages5
JournalJournal of Infectious Diseases
Volume183
Issue number12
DOIs
StatePublished - Jun 15 2001
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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