Macromolecular naloxone: A novel long-acting polymer-bound drug

Gavril W. Pasternak, Steven C. March, Indu Parikh, Solomon H Snyder, Pedro Cuatrecasas

Research output: Contribution to journalArticle

Abstract

A widely applicable, prolonged-action drug delivery system has been developed using naloxone, a pure narcotic antagonist, as a model. The drug is attached to an inert, water soluble polymer by reversible covalent bonds, whose slow cleavage releases active drug. Naloxone, attached to a hydrazine-substituted polysaccharide by a hydrazone bond, antagonizes morphine analgesia more than 25 times longer than free naloxone.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalLife Sciences
Volume18
Issue number9
DOIs
StatePublished - May 1 1976

Fingerprint

Naloxone
Polymers
hydrazine
Pharmaceutical Preparations
Hydrazones
Covalent bonds
Narcotic Antagonists
Drug Delivery Systems
Analgesia
Morphine
Polysaccharides
Water

ASJC Scopus subject areas

  • Pharmacology

Cite this

Pasternak, G. W., March, S. C., Parikh, I., Snyder, S. H., & Cuatrecasas, P. (1976). Macromolecular naloxone: A novel long-acting polymer-bound drug. Life Sciences, 18(9), 977-981. https://doi.org/10.1016/0024-3205(76)90418-5

Macromolecular naloxone : A novel long-acting polymer-bound drug. / Pasternak, Gavril W.; March, Steven C.; Parikh, Indu; Snyder, Solomon H; Cuatrecasas, Pedro.

In: Life Sciences, Vol. 18, No. 9, 01.05.1976, p. 977-981.

Research output: Contribution to journalArticle

Pasternak, GW, March, SC, Parikh, I, Snyder, SH & Cuatrecasas, P 1976, 'Macromolecular naloxone: A novel long-acting polymer-bound drug', Life Sciences, vol. 18, no. 9, pp. 977-981. https://doi.org/10.1016/0024-3205(76)90418-5
Pasternak, Gavril W. ; March, Steven C. ; Parikh, Indu ; Snyder, Solomon H ; Cuatrecasas, Pedro. / Macromolecular naloxone : A novel long-acting polymer-bound drug. In: Life Sciences. 1976 ; Vol. 18, No. 9. pp. 977-981.
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