TY - JOUR
T1 - Macromolecular naloxone
T2 - A novel long-acting polymer-bound drug
AU - Pasternak, Gavril W.
AU - March, Steven C.
AU - Parikh, Indu
AU - Snyder, Solomon H.
AU - Cuatrecasas, Pedro
N1 - Funding Information:
These studies were supported by a grant from Dynapol Corp. G.W.P. is supported by The Mutual of Omaha and United Benefit Life Insurance Companies through the Insurance Medical Scientist Scholarship Fund. S.C.M. is supported in part by USPHS NIH Fellowship HL 01328. S.H.S. (MH 33128) and P.C. (AM 31464) are recipients of Research Scientist Development Awards. Naloxone was the generous gift of the Endo Drug Company.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1976/5/1
Y1 - 1976/5/1
N2 - A widely applicable, prolonged-action drug delivery system has been developed using naloxone, a pure narcotic antagonist, as a model. The drug is attached to an inert, water soluble polymer by reversible covalent bonds, whose slow cleavage releases active drug. Naloxone, attached to a hydrazine-substituted polysaccharide by a hydrazone bond, antagonizes morphine analgesia more than 25 times longer than free naloxone.
AB - A widely applicable, prolonged-action drug delivery system has been developed using naloxone, a pure narcotic antagonist, as a model. The drug is attached to an inert, water soluble polymer by reversible covalent bonds, whose slow cleavage releases active drug. Naloxone, attached to a hydrazine-substituted polysaccharide by a hydrazone bond, antagonizes morphine analgesia more than 25 times longer than free naloxone.
UR - http://www.scopus.com/inward/record.url?scp=0017194853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017194853&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(76)90418-5
DO - 10.1016/0024-3205(76)90418-5
M3 - Article
C2 - 1271967
AN - SCOPUS:0017194853
SN - 0024-3205
VL - 18
SP - 977
EP - 981
JO - Life Sciences
JF - Life Sciences
IS - 9
ER -