Macromolecular naloxone: A novel long-acting polymer-bound drug

Gavril W. Pasternak, Steven C. March, Indu Parikh, Solomon H. Snyder, Pedro Cuatrecasas

Research output: Contribution to journalArticlepeer-review

Abstract

A widely applicable, prolonged-action drug delivery system has been developed using naloxone, a pure narcotic antagonist, as a model. The drug is attached to an inert, water soluble polymer by reversible covalent bonds, whose slow cleavage releases active drug. Naloxone, attached to a hydrazine-substituted polysaccharide by a hydrazone bond, antagonizes morphine analgesia more than 25 times longer than free naloxone.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalLife Sciences
Volume18
Issue number9
DOIs
StatePublished - May 1 1976

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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