Macrolide immunomodulatory effects and symptom resolution in acute exacerbation of chronic bronchitis and acute maxillary sinusitis: A focus on clarithromycin

Research output: Contribution to journalArticle


Bacterial respiratory tract infections are common in the primary care setting and patients often seek the assistance of a healthcare professional in order to achieve resolution of their symptoms. Antibiotic agents that offer rapid symptom relief, in addition to excellent bacteriological and clinical cure, are highly desired. Macrolides have proven to be highly effective in treating acute bacterial exacerbations of chronic bronchitis and acute maxillary sinusitis. In addition, immunomodulatory effects that may contribute to symptom resolution have been reported. This article reviews current literature on symptom resolution in acute bacterial exacerbations of chronic bronchitis and acute maxillary sinusitis, with a focus on clarithromycin, and explores the potential mechanisms that may contribute to this action.

Original languageEnglish (US)
Pages (from-to)405-416
Number of pages12
JournalExpert Review of Anti-Infective Therapy
Issue number3
Publication statusPublished - Jun 2006



  • Extended-release clarithromycin
  • Immunomodulatory effects
  • Symptom resolution

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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