Macro-and microstructural changes in patients with spinocerebellar ataxia type 6: Assessment of phylogenetic subdivisions of the cerebellum and the brain stem

Kanako Sato, K. Ishigame, S. H. Ying, Kenichi Oishi, M. I. Miller, Susumu Mori

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Site-specific degeneration patterns of the infratentorial brain in relation to phylogenetic origins may relate to symptoms in patients with spinocerebellar degeneration, but the patterns are still unclear. We investigated macro-and microstructural changes of the infratentorial brain based on phylogenetic origins and their correlation with symptoms in patients with spinocerebellar ataxia type 6. Materials and Methods: MR images of 9 patients with spinocerebellar ataxia type 6 and 9 age-and sex-matched controls were obtained. Wedivided the infratentorial brain on the basis of phylogenetic origins and performed an atlas-based analysis. Comparisons of the 2 groups and a correlation analysis assessed with the International Cooperative Ataxia Rating Scale excluding age effects were performed. Results: A significant decrease of fractional volume and an increase of mean diffusivity were seen in all subdivisions of the cerebellum and in all the cerebellar peduncles except mean diffusivity in the inferior cerebellar peduncle in patients compared with controls (P

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015

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Spinocerebellar Ataxias
Cerebellum
Brain Stem
Brain
Spinocerebellar Degenerations
Atlases
Ataxia

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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Macro-and microstructural changes in patients with spinocerebellar ataxia type 6 : Assessment of phylogenetic subdivisions of the cerebellum and the brain stem. / Sato, Kanako; Ishigame, K.; Ying, S. H.; Oishi, Kenichi; Miller, M. I.; Mori, Susumu.

In: American Journal of Neuroradiology, Vol. 36, No. 1, 01.01.2015, p. 84-90.

Research output: Contribution to journalArticle

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