Abstract
Background and Purpose: Site-specific degeneration patterns of the infratentorial brain in relation to phylogenetic origins may relate to symptoms in patients with spinocerebellar degeneration, but the patterns are still unclear. We investigated macro-and microstructural changes of the infratentorial brain based on phylogenetic origins and their correlation with symptoms in patients with spinocerebellar ataxia type 6. Materials and Methods: MR images of 9 patients with spinocerebellar ataxia type 6 and 9 age-and sex-matched controls were obtained. Wedivided the infratentorial brain on the basis of phylogenetic origins and performed an atlas-based analysis. Comparisons of the 2 groups and a correlation analysis assessed with the International Cooperative Ataxia Rating Scale excluding age effects were performed. Results: A significant decrease of fractional volume and an increase of mean diffusivity were seen in all subdivisions of the cerebellum and in all the cerebellar peduncles except mean diffusivity in the inferior cerebellar peduncle in patients compared with controls (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 84-90 |
| Number of pages | 7 |
| Journal | American Journal of Neuroradiology |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
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ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging
Cite this
Macro-and microstructural changes in patients with spinocerebellar ataxia type 6 : Assessment of phylogenetic subdivisions of the cerebellum and the brain stem. / Sato, Kanako; Ishigame, K.; Ying, S. H.; Oishi, Kenichi; Miller, M. I.; Mori, Susumu.
In: American Journal of Neuroradiology, Vol. 36, No. 1, 01.01.2015, p. 84-90.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Macro-and microstructural changes in patients with spinocerebellar ataxia type 6
T2 - Assessment of phylogenetic subdivisions of the cerebellum and the brain stem
AU - Sato, Kanako
AU - Ishigame, K.
AU - Ying, S. H.
AU - Oishi, Kenichi
AU - Miller, M. I.
AU - Mori, Susumu
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background and Purpose: Site-specific degeneration patterns of the infratentorial brain in relation to phylogenetic origins may relate to symptoms in patients with spinocerebellar degeneration, but the patterns are still unclear. We investigated macro-and microstructural changes of the infratentorial brain based on phylogenetic origins and their correlation with symptoms in patients with spinocerebellar ataxia type 6. Materials and Methods: MR images of 9 patients with spinocerebellar ataxia type 6 and 9 age-and sex-matched controls were obtained. Wedivided the infratentorial brain on the basis of phylogenetic origins and performed an atlas-based analysis. Comparisons of the 2 groups and a correlation analysis assessed with the International Cooperative Ataxia Rating Scale excluding age effects were performed. Results: A significant decrease of fractional volume and an increase of mean diffusivity were seen in all subdivisions of the cerebellum and in all the cerebellar peduncles except mean diffusivity in the inferior cerebellar peduncle in patients compared with controls (P
AB - Background and Purpose: Site-specific degeneration patterns of the infratentorial brain in relation to phylogenetic origins may relate to symptoms in patients with spinocerebellar degeneration, but the patterns are still unclear. We investigated macro-and microstructural changes of the infratentorial brain based on phylogenetic origins and their correlation with symptoms in patients with spinocerebellar ataxia type 6. Materials and Methods: MR images of 9 patients with spinocerebellar ataxia type 6 and 9 age-and sex-matched controls were obtained. Wedivided the infratentorial brain on the basis of phylogenetic origins and performed an atlas-based analysis. Comparisons of the 2 groups and a correlation analysis assessed with the International Cooperative Ataxia Rating Scale excluding age effects were performed. Results: A significant decrease of fractional volume and an increase of mean diffusivity were seen in all subdivisions of the cerebellum and in all the cerebellar peduncles except mean diffusivity in the inferior cerebellar peduncle in patients compared with controls (P
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UR - http://www.scopus.com/inward/citedby.url?scp=84920942501&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A4085
DO - 10.3174/ajnr.A4085
M3 - Article
C2 - 25169926
AN - SCOPUS:84920942501
VL - 36
SP - 84
EP - 90
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
SN - 0195-6108
IS - 1
ER -