TY - JOUR
T1 - M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds
AU - Wang, Youhan
AU - Smith, Wanli
AU - Hao, Dingjun
AU - He, Baorong
AU - Kong, Lingbo
N1 - Publisher Copyright:
© 2019
PY - 2019/5
Y1 - 2019/5
N2 - Macrophages, as crucial cellular components of innate immunity, are characterized by possessing high plasticity and an abnormal ability to differentiate in response to numerous stimuli. Given this, macrophages show extreme heterogeneity under both physiological and pathological conditions. Typically, macrophages can be polarized into classically activated macrophages (M1) and alternatively activated macrophages (M2) depending on their environment. The relative functions of these two subtypes are almost exactly opposed to one another. Recent studies have suggested that some naturally occurring compounds can exert regulatory effects on the progression of macrophage polarization, which implies that they could be promising therapeutic tools to treat relevant diseases. Therefore, in our current review, we summarize recent studies on several naturally occurring compounds that may possess the ability to regulate macrophage polarization and explore the associated molecular mechanisms.
AB - Macrophages, as crucial cellular components of innate immunity, are characterized by possessing high plasticity and an abnormal ability to differentiate in response to numerous stimuli. Given this, macrophages show extreme heterogeneity under both physiological and pathological conditions. Typically, macrophages can be polarized into classically activated macrophages (M1) and alternatively activated macrophages (M2) depending on their environment. The relative functions of these two subtypes are almost exactly opposed to one another. Recent studies have suggested that some naturally occurring compounds can exert regulatory effects on the progression of macrophage polarization, which implies that they could be promising therapeutic tools to treat relevant diseases. Therefore, in our current review, we summarize recent studies on several naturally occurring compounds that may possess the ability to regulate macrophage polarization and explore the associated molecular mechanisms.
KW - Inflammation
KW - M1
KW - M2
KW - Macrophage
KW - Naturally occurring compounds
UR - http://www.scopus.com/inward/record.url?scp=85062670705&partnerID=8YFLogxK
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U2 - 10.1016/j.intimp.2019.02.050
DO - 10.1016/j.intimp.2019.02.050
M3 - Review article
C2 - 30861466
AN - SCOPUS:85062670705
SN - 1567-5769
VL - 70
SP - 459
EP - 466
JO - International immunopharmacology
JF - International immunopharmacology
ER -