Lymphomas and leukemias in the relatives of patients with mycosis fungoides

Mark H. Greene, Harlan A. Pinto, Jeffrey A. Kant, Kathleen Siler, Eric C. Vonderheid, Stanford I. Lamberg, Nancy A. Dalager

Research output: Contribution to journalArticlepeer-review

Abstract

Of 526 consecutive patients with cutaneous T‐cell lymphomas, 21 had first‐degree relatives with lymphoproliferative or hematopoietic malignancies. Twenty‐nine such tumors occurred in the 21 kindreds. Hodgkin's disease accounted for one‐third of this total, with various leukemias (11 cases), non‐Hodgkin's lymphoma (five cases), and multiple myeloma (three cases) comprising the remainder. These data suggest that genetically‐determined immunoregulatory abnormalities may represent a shared pathway of oncogenesis in diverse lymphoproliferative and hematopoietic malignancies.

Original languageEnglish (US)
Pages (from-to)737-741
Number of pages5
JournalCancer
Volume49
Issue number4
DOIs
StatePublished - Feb 15 1982

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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