Lymphoma in inflammatory bowel disease

A. J. Greenstein, Gerard Mullin, J. A. Strauchen, T. Heimann, H. D. Janowitz, A. H. Aufses, D. B. Sachar

Research output: Contribution to journalArticle

Abstract

Nine patients with lymphoma occurring in association with inflammatory bowel disease were admitted to The Mount Sinai Hospital between 1960 and 1983. Five (two men and three women) occurred among 1156 patients (0.43%) with ulcerative colitis (UC) and four (men), among 1480 patients (0.27%) with Crohn's disease (CD), a strong male preponderance in the latter group. In all four of the patients with CD and in four of the five patients with UC, the lymphomas were extraintestinal. The mean age of onset of UC in these patients was late (46 years, 19 years older than in our overall series), with lymphomas occurring a mean of only 12 years later. By contrast, patients with CD had bowel disease much younger (mean age, 26 years), and their lymphomas appeared after a longer disease duration (mean, 24 years). The risk factors for the one patient with colonic lymphoma were similar to those with colitis- associated colorectal carcinoma: extensive and long-standing colitis and relatively young age when malignant disease developed. Four of the patients with lymphoma had associated colonic carcinoma; in three of them, the carcinoma appeared within the first decade of colitis, an unusual occurrence. A second malignant lesion also occurred in three patients with UC.

Original languageEnglish (US)
Pages (from-to)1119-1123
Number of pages5
JournalCancer
Volume69
Issue number5
StatePublished - 1992

Fingerprint

Inflammatory Bowel Diseases
Lymphoma
Ulcerative Colitis
Colitis
Crohn Disease
Carcinoma
Age of Onset
Colorectal Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Greenstein, A. J., Mullin, G., Strauchen, J. A., Heimann, T., Janowitz, H. D., Aufses, A. H., & Sachar, D. B. (1992). Lymphoma in inflammatory bowel disease. Cancer, 69(5), 1119-1123.

Lymphoma in inflammatory bowel disease. / Greenstein, A. J.; Mullin, Gerard; Strauchen, J. A.; Heimann, T.; Janowitz, H. D.; Aufses, A. H.; Sachar, D. B.

In: Cancer, Vol. 69, No. 5, 1992, p. 1119-1123.

Research output: Contribution to journalArticle

Greenstein, AJ, Mullin, G, Strauchen, JA, Heimann, T, Janowitz, HD, Aufses, AH & Sachar, DB 1992, 'Lymphoma in inflammatory bowel disease', Cancer, vol. 69, no. 5, pp. 1119-1123.
Greenstein AJ, Mullin G, Strauchen JA, Heimann T, Janowitz HD, Aufses AH et al. Lymphoma in inflammatory bowel disease. Cancer. 1992;69(5):1119-1123.
Greenstein, A. J. ; Mullin, Gerard ; Strauchen, J. A. ; Heimann, T. ; Janowitz, H. D. ; Aufses, A. H. ; Sachar, D. B. / Lymphoma in inflammatory bowel disease. In: Cancer. 1992 ; Vol. 69, No. 5. pp. 1119-1123.
@article{20dbd629cfdb4a84b36d6af00477f2d8,
title = "Lymphoma in inflammatory bowel disease",
abstract = "Nine patients with lymphoma occurring in association with inflammatory bowel disease were admitted to The Mount Sinai Hospital between 1960 and 1983. Five (two men and three women) occurred among 1156 patients (0.43{\%}) with ulcerative colitis (UC) and four (men), among 1480 patients (0.27{\%}) with Crohn's disease (CD), a strong male preponderance in the latter group. In all four of the patients with CD and in four of the five patients with UC, the lymphomas were extraintestinal. The mean age of onset of UC in these patients was late (46 years, 19 years older than in our overall series), with lymphomas occurring a mean of only 12 years later. By contrast, patients with CD had bowel disease much younger (mean age, 26 years), and their lymphomas appeared after a longer disease duration (mean, 24 years). The risk factors for the one patient with colonic lymphoma were similar to those with colitis- associated colorectal carcinoma: extensive and long-standing colitis and relatively young age when malignant disease developed. Four of the patients with lymphoma had associated colonic carcinoma; in three of them, the carcinoma appeared within the first decade of colitis, an unusual occurrence. A second malignant lesion also occurred in three patients with UC.",
author = "Greenstein, {A. J.} and Gerard Mullin and Strauchen, {J. A.} and T. Heimann and Janowitz, {H. D.} and Aufses, {A. H.} and Sachar, {D. B.}",
year = "1992",
language = "English (US)",
volume = "69",
pages = "1119--1123",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Lymphoma in inflammatory bowel disease

AU - Greenstein, A. J.

AU - Mullin, Gerard

AU - Strauchen, J. A.

AU - Heimann, T.

AU - Janowitz, H. D.

AU - Aufses, A. H.

AU - Sachar, D. B.

PY - 1992

Y1 - 1992

N2 - Nine patients with lymphoma occurring in association with inflammatory bowel disease were admitted to The Mount Sinai Hospital between 1960 and 1983. Five (two men and three women) occurred among 1156 patients (0.43%) with ulcerative colitis (UC) and four (men), among 1480 patients (0.27%) with Crohn's disease (CD), a strong male preponderance in the latter group. In all four of the patients with CD and in four of the five patients with UC, the lymphomas were extraintestinal. The mean age of onset of UC in these patients was late (46 years, 19 years older than in our overall series), with lymphomas occurring a mean of only 12 years later. By contrast, patients with CD had bowel disease much younger (mean age, 26 years), and their lymphomas appeared after a longer disease duration (mean, 24 years). The risk factors for the one patient with colonic lymphoma were similar to those with colitis- associated colorectal carcinoma: extensive and long-standing colitis and relatively young age when malignant disease developed. Four of the patients with lymphoma had associated colonic carcinoma; in three of them, the carcinoma appeared within the first decade of colitis, an unusual occurrence. A second malignant lesion also occurred in three patients with UC.

AB - Nine patients with lymphoma occurring in association with inflammatory bowel disease were admitted to The Mount Sinai Hospital between 1960 and 1983. Five (two men and three women) occurred among 1156 patients (0.43%) with ulcerative colitis (UC) and four (men), among 1480 patients (0.27%) with Crohn's disease (CD), a strong male preponderance in the latter group. In all four of the patients with CD and in four of the five patients with UC, the lymphomas were extraintestinal. The mean age of onset of UC in these patients was late (46 years, 19 years older than in our overall series), with lymphomas occurring a mean of only 12 years later. By contrast, patients with CD had bowel disease much younger (mean age, 26 years), and their lymphomas appeared after a longer disease duration (mean, 24 years). The risk factors for the one patient with colonic lymphoma were similar to those with colitis- associated colorectal carcinoma: extensive and long-standing colitis and relatively young age when malignant disease developed. Four of the patients with lymphoma had associated colonic carcinoma; in three of them, the carcinoma appeared within the first decade of colitis, an unusual occurrence. A second malignant lesion also occurred in three patients with UC.

UR - http://www.scopus.com/inward/record.url?scp=0026565590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026565590&partnerID=8YFLogxK

M3 - Article

C2 - 1739911

AN - SCOPUS:0026565590

VL - 69

SP - 1119

EP - 1123

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 5

ER -