Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: Results of the AIDS Clinical Trials Group A5211

Athe M N Tsibris, Roger Paredes, Amy Chadburn, Zhaohui Su, Timothy J. Henrich, Amy Krambrink, Michael D. Hughes, Judith A. Aberg, Judith S. Currier, Karen Tashima, Catherine Godfrey, Wayne Greaves, Charles Williams Flexner, Paul R. Skolnik, Timothy J. Wilkin, Roy M. Gulick, Daniel R. Kuritzkes

Research output: Contribution to journalArticle

Abstract

Background. Lack of functional CCR5 increases the severity of certain viral infections, including West Nile virus and tickborne encephalitis. In a phase II trial of the investigational CCR5 antagonist vicriviroc (AIDS Clinical Trials Group protocol A5211), 4 lymphomas occurred in study patients who received vicriviroc. Because of the known association between unregulated Epstein-Barr virus (EBV) replication and lymphoma in immunocompromised patients, we evaluated whether vicriviroc exposure was associated with lymphoma EBV antigen positivity and/or had an effect on plasma levels of EBV DNA. Methods. Clinical findings for all 4 patients enrolled in the A5211 study who developed lymphoma (2 Hodgkin and 2 non-Hodgkin) were reviewed, and tumor specimens were assessed for evidence of ongoing EBV replication. Longitudinal plasma samples from 116 patients in the A5211 study were analyzed, and EBV DNA was quantified by real-time polymerase chain reaction. Results. Plasma EBV DNA was not detected in the 2 patients with non-Hodgkin lymphoma; both patients with Hodgkin lymphoma who had samples tested had EBV DNA levels

Original languageEnglish (US)
Pages (from-to)642-649
Number of pages8
JournalClinical Infectious Diseases
Volume48
Issue number5
DOIs
Publication statusPublished - Mar 1 2009

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ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

Cite this

Tsibris, A. M. N., Paredes, R., Chadburn, A., Su, Z., Henrich, T. J., Krambrink, A., ... Kuritzkes, D. R. (2009). Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: Results of the AIDS Clinical Trials Group A5211. Clinical Infectious Diseases, 48(5), 642-649. https://doi.org/10.1086/597007