Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells

E. A. Grimm, R. J. Robb, J. A. Roth, L. M. Neckers, L. B. Lachman, D. J. Wilson, S. A. Rosenberg

Research output: Contribution to journalArticle

Abstract

Purified interleukin 2 (IL-2) was found to be sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer (LAK) cells. The LAK activation factor was directly and consistently associated with IL-2 activity using classic protein purification techniques, adsorption to IL-2-dependent cell lines, and inhibition with anti-Tac antibody. As yet, no other cytokines have been found that perform the same role.

Original languageEnglish (US)
Pages (from-to)1356-1361
Number of pages6
JournalJournal of Experimental Medicine
Volume158
Issue number4
StatePublished - 1983
Externally publishedYes

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Lymphokine-Activated Killer Cells
Interleukin-2
Lymphocytes
Lymphokines
Adsorption
Anti-Idiotypic Antibodies
Cytokines
Cell Line
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells. / Grimm, E. A.; Robb, R. J.; Roth, J. A.; Neckers, L. M.; Lachman, L. B.; Wilson, D. J.; Rosenberg, S. A.

In: Journal of Experimental Medicine, Vol. 158, No. 4, 1983, p. 1356-1361.

Research output: Contribution to journalArticle

Grimm, E. A. ; Robb, R. J. ; Roth, J. A. ; Neckers, L. M. ; Lachman, L. B. ; Wilson, D. J. ; Rosenberg, S. A. / Lymphokine-activated killer cell phenomenon. III. Evidence that IL-2 is sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer cells. In: Journal of Experimental Medicine. 1983 ; Vol. 158, No. 4. pp. 1356-1361.
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