Lymphocytic infundibulo-neurohypophysitis: a clinical overview

Philip C. Johnston, Luen S. Chew, Amir H. Hamrahian, Laurence Kennedy

Research output: Contribution to journalReview article

Abstract

Lymphocytic infundibulo-neurohypophysitis is an uncommon inflammatory disorder postulated to be autoimmune in origin. Because of the location of inflammation, it selectively affects the posterior lobe of the pituitary (neurohypophysis) and pituitary stalk (infundibulum). The most common presentation is central diabetes insipidus. Although the definitive diagnosis is established histologically by a pituitary biopsy, radiological imaging can be valuable in diagnosing this condition. In this paper, we provide an overview of the pathophysiology, investigations, management, and outcomes of lymphocytic infundibulo-neurohypophysitis.

Original languageEnglish (US)
Pages (from-to)531-536
Number of pages6
JournalEndocrine
Volume50
Issue number3
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Keywords

  • Anterior and posterior pituitary function
  • Central diabetes insipidus
  • Lymphocytic infundibulo-neurohypophysitis
  • Pituitary gland

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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