Lymphocyte transformation in patients with staged mycosis fungoides and Sezary syndrome

A. Du Vivier, R. A. Harper, E. Vonderheid, E. J. Van Scott

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Abstract

Lymphocyte transformation was studied in patients with mycosis fungoides and the Sezary syndrome with particular reference to the stage of disease. Phytohemagglutinin-induced lymphocyte blastogenesis was normal in stage II, became depressed in stage III and was greatly reduced in stage IV disease. Similar abnormalities were found in patients with the Sezary syndrome once the proportion of abnormal cells in the peripheral blood exceeded 10%. It is concluded that stage III mycosis fungoides is probably a critical period in determining dissemination of the disease.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalCancer
Volume42
Issue number1
Publication statusPublished - 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Du Vivier, A., Harper, R. A., Vonderheid, E., & Van Scott, E. J. (1978). Lymphocyte transformation in patients with staged mycosis fungoides and Sezary syndrome. Cancer, 42(1), 209-213.