Lymphocyte transformation was studied in patients with mycosis fungoides and the Sezary syndrome with particular reference to the stage of disease. Phytohemagglutinin-induced lymphocyte blastogenesis was normal in stage II, became depressed in stage III and was greatly reduced in stage IV disease. Similar abnormalities were found in patients with the Sezary syndrome once the proportion of abnormal cells in the peripheral blood exceeded 10%. It is concluded that stage III mycosis fungoides is probably a critical period in determining dissemination of the disease.
|Original language||English (US)|
|Number of pages||5|
|Publication status||Published - 1978|
ASJC Scopus subject areas
- Cancer Research