Lymphocyte-rich well-differentiated liposarcoma

Report of nine cases

Pedram Argani, Fabio Facchetti, Giorgio Inghirami, Juan Rosai

Research output: Contribution to journalArticle

Abstract

Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.

Original languageEnglish (US)
Pages (from-to)884-895
Number of pages12
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number8
DOIs
StatePublished - 1997

Fingerprint

Liposarcoma
Lymphocytes
Plasma Cell Granuloma
Giant Lymph Node Hyperplasia
T-Cell Receptor Genes
Germinal Center
Stromal Cells
Hodgkin Disease
Blood Vessels
Molecular Biology
Lymphoma
Neoplasms
Differential Diagnosis
Collagen
T-Lymphocytes
Population

Keywords

  • Castleman's disease
  • Inflammatory
  • Liposarcoma
  • Lymphoma
  • Pseudolymphoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Lymphocyte-rich well-differentiated liposarcoma : Report of nine cases. / Argani, Pedram; Facchetti, Fabio; Inghirami, Giorgio; Rosai, Juan.

In: American Journal of Surgical Pathology, Vol. 21, No. 8, 1997, p. 884-895.

Research output: Contribution to journalArticle

Argani, Pedram ; Facchetti, Fabio ; Inghirami, Giorgio ; Rosai, Juan. / Lymphocyte-rich well-differentiated liposarcoma : Report of nine cases. In: American Journal of Surgical Pathology. 1997 ; Vol. 21, No. 8. pp. 884-895.
@article{af0a55da8f9049d98c880fd480df0ea0,
title = "Lymphocyte-rich well-differentiated liposarcoma: Report of nine cases",
abstract = "Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.",
keywords = "Castleman's disease, Inflammatory, Liposarcoma, Lymphoma, Pseudolymphoma",
author = "Pedram Argani and Fabio Facchetti and Giorgio Inghirami and Juan Rosai",
year = "1997",
doi = "10.1097/00000478-199708000-00002",
language = "English (US)",
volume = "21",
pages = "884--895",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Lymphocyte-rich well-differentiated liposarcoma

T2 - Report of nine cases

AU - Argani, Pedram

AU - Facchetti, Fabio

AU - Inghirami, Giorgio

AU - Rosai, Juan

PY - 1997

Y1 - 1997

N2 - Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.

AB - Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.

KW - Castleman's disease

KW - Inflammatory

KW - Liposarcoma

KW - Lymphoma

KW - Pseudolymphoma

UR - http://www.scopus.com/inward/record.url?scp=0030771957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030771957&partnerID=8YFLogxK

U2 - 10.1097/00000478-199708000-00002

DO - 10.1097/00000478-199708000-00002

M3 - Article

VL - 21

SP - 884

EP - 895

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 8

ER -