Lymphocyte-rich well-differentiated liposarcoma: Report of nine cases

Pedram Argani, Fabio Facchetti, Giorgio Inghirami, Juan Rosai

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.

Original languageEnglish (US)
Pages (from-to)884-895
Number of pages12
JournalAmerican Journal of Surgical Pathology
Issue number8
StatePublished - Oct 3 1997


  • Castleman's disease
  • Inflammatory
  • Liposarcoma
  • Lymphoma
  • Pseudolymphoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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