TY - JOUR
T1 - Lymphocyte-rich well-differentiated liposarcoma
T2 - Report of nine cases
AU - Argani, Pedram
AU - Facchetti, Fabio
AU - Inghirami, Giorgio
AU - Rosai, Juan
PY - 1997/10/3
Y1 - 1997/10/3
N2 - Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.
AB - Nine well-differentiated liposarcomas with loci simulating the appearance of malignant lymphoma and other lymphoid disorders are reported. Their clinical presentation and evolution were not significantly different from those of their conventional counterparts lacking a lymphoid infiltrate. Microscopically, these tumors were characterized by areas of ordinary well- differentiated liposarcoma, admixed with discrete nodules comprised of small germinal centers, and separated by an admixture of lymphocytes, spindled stromal cells, collagen, and blood vessels, in which highly atypical tumor cells were embedded. The differential diagnosis included Hodgkin's disease, Castleman's disease, and inflammatory pseudotumor. Immunohistochemical evaluation revealed a predominance of T cells in the lymphocytic population. Molecular genetic studies revealed no evidence of clonal rearrangement of the T cell receptor gene, supporting the interpretation of these lymphocytes as reactive. Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.
KW - Castleman's disease
KW - Inflammatory
KW - Liposarcoma
KW - Lymphoma
KW - Pseudolymphoma
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U2 - 10.1097/00000478-199708000-00002
DO - 10.1097/00000478-199708000-00002
M3 - Article
C2 - 9255251
AN - SCOPUS:0030771957
SN - 0147-5185
VL - 21
SP - 884
EP - 895
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 8
ER -