Lymphatic and blood vessel density in human conjunctiva after glaucoma filtration surgery

Rachida A. Bouhenni; Ibrahim Al Jadaan; Heidi Rassavong; Sami Al Shahwan; Hind Al Katan; Jeffrey Dunmire; Mirela Krasniqi; Deepak P. Edward

doi:10.1097/IJG.0000000000000199

Lymphatic and blood vessel density in human conjunctiva after glaucoma filtration surgery

Rachida A. Bouhenni, Ibrahim Al Jadaan, Heidi Rassavong, Sami Al Shahwan, Hind Al Katan, Jeffrey Dunmire, Mirela Krasniqi, Deepak P. Edward

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To investigate the lymphatic vascular microvessel density (LVD) and the blood vascular microvessel density (MVD) and their distribution in excised leaking blebs after mitomycin C trabeculectomy and normal conjunctiva specimens. Materials and Methods: LVD and MVD in normal human conjunctiva (n=8) and excised blebs in the hypocellular stroma and peribleb tissue (conjunctiva adjacent to hypocellular bleb tissue) (n=8) were evaluated by immunohistochemistry using antibodies raised against Lymphatic Vessel Endothelial Receptor 1 (D2-40, lymphatic endothelium) and CD34 (vascular endothelium). LVD and MVD counts were performed by light microscopyin 5 fields at ×20 magnification by 3 observers. Differences were determined using Mann-Whitney U test (P

Original language	English (US)
Pages (from-to)	e35-e38
Journal	Journal of Glaucoma
Volume	25
Issue number	1
DOIs	https://doi.org/10.1097/IJG.0000000000000199
State	Published - 2016

Keywords

Blebitis
Lymphatic vessels
Mitomycin c
Trabeculectomy

ASJC Scopus subject areas

Ophthalmology

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10.1097/IJG.0000000000000199

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title = "Lymphatic and blood vessel density in human conjunctiva after glaucoma filtration surgery",

abstract = "Purpose: To investigate the lymphatic vascular microvessel density (LVD) and the blood vascular microvessel density (MVD) and their distribution in excised leaking blebs after mitomycin C trabeculectomy and normal conjunctiva specimens. Materials and Methods: LVD and MVD in normal human conjunctiva (n=8) and excised blebs in the hypocellular stroma and peribleb tissue (conjunctiva adjacent to hypocellular bleb tissue) (n=8) were evaluated by immunohistochemistry using antibodies raised against Lymphatic Vessel Endothelial Receptor 1 (D2-40, lymphatic endothelium) and CD34 (vascular endothelium). LVD and MVD counts were performed by light microscopyin 5 fields at ×20 magnification by 3 observers. Differences were determined using Mann-Whitney U test (P",

keywords = "Blebitis, Lymphatic vessels, Mitomycin c, Trabeculectomy",

author = "Bouhenni, {Rachida A.} and Jadaan, {Ibrahim Al} and Heidi Rassavong and Shahwan, {Sami Al} and Katan, {Hind Al} and Jeffrey Dunmire and Mirela Krasniqi and Edward, {Deepak P.}",

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T1 - Lymphatic and blood vessel density in human conjunctiva after glaucoma filtration surgery

AU - Bouhenni, Rachida A.

AU - Jadaan, Ibrahim Al

AU - Rassavong, Heidi

AU - Shahwan, Sami Al

AU - Katan, Hind Al

AU - Dunmire, Jeffrey

AU - Krasniqi, Mirela

AU - Edward, Deepak P.

PY - 2016

Y1 - 2016

N2 - Purpose: To investigate the lymphatic vascular microvessel density (LVD) and the blood vascular microvessel density (MVD) and their distribution in excised leaking blebs after mitomycin C trabeculectomy and normal conjunctiva specimens. Materials and Methods: LVD and MVD in normal human conjunctiva (n=8) and excised blebs in the hypocellular stroma and peribleb tissue (conjunctiva adjacent to hypocellular bleb tissue) (n=8) were evaluated by immunohistochemistry using antibodies raised against Lymphatic Vessel Endothelial Receptor 1 (D2-40, lymphatic endothelium) and CD34 (vascular endothelium). LVD and MVD counts were performed by light microscopyin 5 fields at ×20 magnification by 3 observers. Differences were determined using Mann-Whitney U test (P

AB - Purpose: To investigate the lymphatic vascular microvessel density (LVD) and the blood vascular microvessel density (MVD) and their distribution in excised leaking blebs after mitomycin C trabeculectomy and normal conjunctiva specimens. Materials and Methods: LVD and MVD in normal human conjunctiva (n=8) and excised blebs in the hypocellular stroma and peribleb tissue (conjunctiva adjacent to hypocellular bleb tissue) (n=8) were evaluated by immunohistochemistry using antibodies raised against Lymphatic Vessel Endothelial Receptor 1 (D2-40, lymphatic endothelium) and CD34 (vascular endothelium). LVD and MVD counts were performed by light microscopyin 5 fields at ×20 magnification by 3 observers. Differences were determined using Mann-Whitney U test (P

KW - Blebitis

KW - Lymphatic vessels

KW - Mitomycin c

KW - Trabeculectomy

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