Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia

Christopher Gamper, Clifford M Takemoto, Jeffrey Schowinsky, Michael J Borowitz, Marshall S. Horwitz, John Strouse

Research output: Contribution to journalArticle


We present the cases of two patients with severe congenital neutropenia (SCN) who both developed generalized adenopathy. Although both had recent histories that placed infection high on the differential of causes for the adenopathy, biopsies demonstrated acute myeloid leukemia (AML) as the etiology. The risk of malignant transformation in SCN is known to be significantly elevated, and these cases illustrate the need for physicians of such patients to keep myelodysplastic syndrome (MDS) and AML high on the differential when patients manifest atypical symptoms.

Original languageEnglish (US)
Pages (from-to)1072-1075
Number of pages4
JournalPediatric Blood and Cancer
Issue number5
Publication statusPublished - May 2008



  • Acute myeloid leukemia
  • Congenital neutropenia
  • Lymphadenopathy
  • Monosomy 7

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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