Luteolin isolated from the medicinal plant elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein swedish mutation overexpressing SH-sy5Y cells

Rui Liu, Fanrui Meng, Li Zhang, Ailin Liu, Hailin Qin, Xi Lan, Lin Li, Guanhua Du

Research output: Contribution to journalArticlepeer-review

Abstract

Luteolin, a 3',4',5,7-tetrahydroxyflavone, is a plant flavonoid and pharmacologically active agent that has been isolated from several plant species. In the present study, the effects of luteolin obtained from the medicinal plant Elsholtzia rugulosa and the related mechanisms were examined in an Alzheimer's disease (AD) cell model. In this model, copper was used to exacerbate the neurotoxicity in β-amyloid precursor protein Swedish mutation stably overexpressed SH-SY5Y cells (named "APPsw cells" for short). Based on this model, we demonstrated that luteolin increased cell viability, reduced intracellular ROS generation, enhanced the activity of SOD and reversed mitochondrial membrane potential dissipation. Inhibition of caspase-related apoptosis was consistently involved in the neuroprotection afforded by luteolin. Furthermore, it down-regulated the expression of AβPP and lowered the secretion of Aβ1-42. These results indicated that luteolin from the Elsholtzia rugulosa exerted neroprotective effects through mechanisms that decrease AβPP expression, lower Aβ secretion, regulate the redox imbalance, preserve mitochondrial function, and depress the caspase family-related apoptosis.

Original languageEnglish (US)
Pages (from-to)2084-2096
Number of pages13
JournalMolecules
Volume16
Issue number3
DOIs
StatePublished - Mar 2011
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid-β peptide
  • Copper
  • Elsholtzia rugulosa
  • Luteolin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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