Abstract
Six malignant tumors of the lung with a rhabdoid phenotype are described. All presented as lung masses in middle-aged to elderly adults (mean age 51 years), with no sex predilection. The tumors ranged from 1.3 cm to 8.0 cm in size and were generally associated with locally advanced disease. The distinctive (and defining) histologic feature was the presence of macronucleolated tumor cells with a large eosinophilic globular cytoplasmic inclusion. These 'rhabdoid' elements comprised at least 10% of the neoplastic population. Immunohistochemistry revealed diffuse vimentin positivity in all cases. Epithelial and neuroendocrine markers were at least focally positive in five and in all six cases, respectively. Electron microscopy was performed in one case and it showed paranuclear aggregates of intermediate filaments, dense core granules, and intercellular attachments. Malignant tumors of the lung with a rhabdoid phenotype are very rare. The majority are poorly differentiated carcinomas, and they frequently show features suggesting a neuroendocrine differentiation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 182-188 |
| Number of pages | 7 |
| Journal | American Journal of Clinical Pathology |
| Volume | 105 |
| Issue number | 2 |
| State | Published - Feb 1996 |
| Externally published | Yes |
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Keywords
- Carcinoma
- Lung neoplasms
- Rhabdoid tumors
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Lung tumors with a rhabdoid phenotype. / Cavazza, Alberto; Colby, Thomas V.; Tsokos, Maria; Rush, Walter; Travis, William D.
In: American Journal of Clinical Pathology, Vol. 105, No. 2, 02.1996, p. 182-188.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lung tumors with a rhabdoid phenotype
AU - Cavazza, Alberto
AU - Colby, Thomas V.
AU - Tsokos, Maria
AU - Rush, Walter
AU - Travis, William D.
PY - 1996/2
Y1 - 1996/2
N2 - Six malignant tumors of the lung with a rhabdoid phenotype are described. All presented as lung masses in middle-aged to elderly adults (mean age 51 years), with no sex predilection. The tumors ranged from 1.3 cm to 8.0 cm in size and were generally associated with locally advanced disease. The distinctive (and defining) histologic feature was the presence of macronucleolated tumor cells with a large eosinophilic globular cytoplasmic inclusion. These 'rhabdoid' elements comprised at least 10% of the neoplastic population. Immunohistochemistry revealed diffuse vimentin positivity in all cases. Epithelial and neuroendocrine markers were at least focally positive in five and in all six cases, respectively. Electron microscopy was performed in one case and it showed paranuclear aggregates of intermediate filaments, dense core granules, and intercellular attachments. Malignant tumors of the lung with a rhabdoid phenotype are very rare. The majority are poorly differentiated carcinomas, and they frequently show features suggesting a neuroendocrine differentiation.
AB - Six malignant tumors of the lung with a rhabdoid phenotype are described. All presented as lung masses in middle-aged to elderly adults (mean age 51 years), with no sex predilection. The tumors ranged from 1.3 cm to 8.0 cm in size and were generally associated with locally advanced disease. The distinctive (and defining) histologic feature was the presence of macronucleolated tumor cells with a large eosinophilic globular cytoplasmic inclusion. These 'rhabdoid' elements comprised at least 10% of the neoplastic population. Immunohistochemistry revealed diffuse vimentin positivity in all cases. Epithelial and neuroendocrine markers were at least focally positive in five and in all six cases, respectively. Electron microscopy was performed in one case and it showed paranuclear aggregates of intermediate filaments, dense core granules, and intercellular attachments. Malignant tumors of the lung with a rhabdoid phenotype are very rare. The majority are poorly differentiated carcinomas, and they frequently show features suggesting a neuroendocrine differentiation.
KW - Carcinoma
KW - Lung neoplasms
KW - Rhabdoid tumors
UR - http://www.scopus.com/inward/record.url?scp=0030047139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030047139&partnerID=8YFLogxK
M3 - Article
C2 - 8607442
AN - SCOPUS:0030047139
VL - 105
SP - 182
EP - 188
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 2
ER -