TY - JOUR
T1 - Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice
AU - Krijgsheld, Klaas R.
AU - Lowe, Michael C.
AU - Mimnaugh, Edward G.
AU - Trush, Michael A.
AU - Ginsburg, Erika
AU - Gram, Theodore E.
PY - 1983/1/27
Y1 - 1983/1/27
N2 - The acute toxic effects of 1,1-dichloroethylene (DCE; 125 mg/kg, i.p.) on mouse lung, liver and kidney were investigated 24 hr after its administration. DCE caused a reduction of cytochrome P-450 levels and related monooxygenases in lung microsomes with no corresponding changes in liver and kidney. Examination of the lung tissue by light microscopy revealed necrosis restricted to the Clara cells. In contrast, liver and kidney were relatively unaffected by DCE treatment, as indicated by lack of changes in microsomal monooxygenase activities and morphology.
AB - The acute toxic effects of 1,1-dichloroethylene (DCE; 125 mg/kg, i.p.) on mouse lung, liver and kidney were investigated 24 hr after its administration. DCE caused a reduction of cytochrome P-450 levels and related monooxygenases in lung microsomes with no corresponding changes in liver and kidney. Examination of the lung tissue by light microscopy revealed necrosis restricted to the Clara cells. In contrast, liver and kidney were relatively unaffected by DCE treatment, as indicated by lack of changes in microsomal monooxygenase activities and morphology.
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U2 - 10.1016/0006-291X(83)91202-0
DO - 10.1016/0006-291X(83)91202-0
M3 - Article
C2 - 6838545
AN - SCOPUS:0020683763
SN - 0006-291X
VL - 110
SP - 675
EP - 681
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -