Lung-selective impairment of cytochrome P-450-dependent monooxygenases and cellular injury by 1,1-dichloroethylene in mice

Klaas R. Krijgsheld, Michael C. Lowe, Edward G. Mimnaugh, Michael A. Trush, Erika Ginsburg, Theodore E. Gram

Research output: Contribution to journalArticlepeer-review

Abstract

The acute toxic effects of 1,1-dichloroethylene (DCE; 125 mg/kg, i.p.) on mouse lung, liver and kidney were investigated 24 hr after its administration. DCE caused a reduction of cytochrome P-450 levels and related monooxygenases in lung microsomes with no corresponding changes in liver and kidney. Examination of the lung tissue by light microscopy revealed necrosis restricted to the Clara cells. In contrast, liver and kidney were relatively unaffected by DCE treatment, as indicated by lack of changes in microsomal monooxygenase activities and morphology.

Original languageEnglish (US)
Pages (from-to)675-681
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume110
Issue number2
DOIs
StatePublished - Jan 27 1983

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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