Lung redox homeostasis: Emerging concepts

Marilyn P. Merker, Bruce R. Pitt, Augustine M. Choi, Paul M. Hassoun, Christopher A. Dawson, Aron B. Fisher

Research output: Contribution to journalArticle

Abstract

This symposium was organized to present some aspects of current research pertaining to lung redox function. Focuses of the symposium were on roles of pulmonary endothelial NADPH oxidase, xanthine oxidase (XO)/xanthine dehydrogenase (XDH), heme oxygenase (HO), transplasma membrane electron transport (TPMET), and the zinc binding protein metallothionein (MT) in the propagation and/or protection of the lung or other organs from oxidative injury. The presentations were chosen to reflect the roles of both intracellular (metallothionein, XO/XDH, and HO) and plasma membrane (NADPH oxidase, XO/XDH, and unidentified TPMET) redox proteins in these processes. Although the lung endothelium was the predominant cell type under consideration, at least some of the proposed mechanisms operate in or affect other cell types and organs as well.

Original languageEnglish (US)
Pages (from-to)L413-L417
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume279
Issue number3 23-3
StatePublished - Oct 4 2000

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Keywords

  • Endothelium
  • Oxidation-reduction
  • Oxidative stress

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

Cite this

Merker, M. P., Pitt, B. R., Choi, A. M., Hassoun, P. M., Dawson, C. A., & Fisher, A. B. (2000). Lung redox homeostasis: Emerging concepts. American Journal of Physiology - Lung Cellular and Molecular Physiology, 279(3 23-3), L413-L417.