Lung cancer: Reproducibility of quantitative measurements for evaluating 2-[F-18]-fluoro-2-deoxy-D-glucose uptake at PET

Heikki Minn, Kenneth R. Zasadny, Leslie E. Quint, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To study the precision of repeated 2-[fluorine-18]-fluoro-2- deoxy-D-glucose (FDG) uptake measurements at positron emission tomography (PET) in patients with primary lung cancer. MATERIALS AND METHODS: Ten patients with untreated lung cancer underwent two dynamic FDG PET examinations after a 4-hour fast within 1 week. Kinetic modeling of tumor FDG uptake was performed on the basis of a three-compartment model. The tumor concentration of F-18 (standardized uptake value calculated on the basis of predicted lean body mass [SUV-lean]) was also measured 50-60 minutes after injection of a tracer. Blood glucose, insulin, and free fatty acid levels were monitored. RESULTS: SUV-lean and the FDG influx constant K(i) were measured with a mean ± standard deviation difference of 10% ± 7 and 10% ± 8, respectively, over repeated PET scans. The mean difference was reduced to 6% ± 6 and 6% ± 5 by multiplying SUV-lean and K(i) by plasma glucose concentration. CONCLUSION: SUV-lean and graphical K(i) can be measured reproducibly, supporting their use in quantitative FDG PET algorithms.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalRADIOLOGY
Volume196
Issue number1
DOIs
StatePublished - Jul 1995

Keywords

  • Emission CT (ECT)
  • Fluorine
  • Glucose
  • Lung neoplasms
  • Lung, emission CT (ECT)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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