Lung and vascular function during chronic severe pulmonary ischemia

Elizabeth Marie Wagner, John Jenkins, Maria Grazia Perino, Adlah Sukkar, Wayne A Mitzner

Research output: Contribution to journalArticle

Abstract

Bronchial vascular an-giogenesis takes place in a variety of lung inflammatory conditions such as asthma, cystic fibrosis, lung cancer, and chronic pulmonary thromboembolic disease. However, it is unclear whether neovascular-ization is predominantly appropriate and preserves lung tissue or whether it contributes further to lung pathology through edema formation and inflammation. In the present study we examined airway and lung parenchymal function 14 days after left pulmonary artery ligation. In rats as well as higher mammals, severe pulmonary ischemia results in bronchial vascular proliferation. Using labeled micro-spheres, we demonstrated an 18-fold increase in systemic blood flow to the ischemic left lung. Additionally, vascular remodeling extended to the tracheal venules, which showed an average 28% increase in venular diameter. Despite this increase in vascularity, airways resistance was not altered nor was methacholine responsiveness. Since these measurements include the entire lung, we suggest that the normal right lung, which represented 78% of the total lung, obscured the ability to detect a change. When functional indexes such as diffusing capacity, in situ lung volume, and vascular permeability of the left lung could be separated from right lung, significant changes were observed. Thus when comparing average left lung values of rats 14 days after left pulmonary artery ligation to left lungs of rats undergoing sham surgery, diffusing capacity of the left lung decreased by 72%, left lung volume decreased by 38%, and the vascular permeability to protein increased by 58%. No significant differences in inflammatory cell recruitment were observed, suggesting that acute ischemic inflammation had resolved. We conclude that despite the preservation of lung tissue, the proliferating bronchial neovasculature may contribute to a sustained decrement in pulmonary function.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalJournal of Applied Physiology
Volume110
Issue number2
DOIs
StatePublished - Feb 2011

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Blood Vessels
Ischemia
Lung
Capillary Permeability
Pulmonary Artery
Ligation
Tissue Preservation
Inflammation
Lung Volume Measurements
Airway Resistance
Venules
Methacholine Chloride
Cystic Fibrosis
Lung Diseases
Mammals
Lung Neoplasms
Edema
Asthma

Keywords

  • Angiogenesis
  • Bronchial arteries

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Lung and vascular function during chronic severe pulmonary ischemia. / Wagner, Elizabeth Marie; Jenkins, John; Perino, Maria Grazia; Sukkar, Adlah; Mitzner, Wayne A.

In: Journal of Applied Physiology, Vol. 110, No. 2, 02.2011, p. 538-544.

Research output: Contribution to journalArticle

Wagner, Elizabeth Marie ; Jenkins, John ; Perino, Maria Grazia ; Sukkar, Adlah ; Mitzner, Wayne A. / Lung and vascular function during chronic severe pulmonary ischemia. In: Journal of Applied Physiology. 2011 ; Vol. 110, No. 2. pp. 538-544.
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