Luminal adrenergic agents modulate intestinal transport

J. Augusto Bastidas, Robert E. Schmieg, Charles J. Yeo, Michael J. Zinner

Research output: Contribution to journalArticle

Abstract

Intestinal transport is controlled by luminal solutes, neural pathways, and paracrine or humoral agents. The current study investigated the effect of luminally administered adrenergic agents on the intestinal transport of water and electrolytes. Dogs with 25-cm jejunal Thiry-Vella loops were studied. The loops were luminally perfused with an isotonic solution containing [14C]PEG, and the fluxes of H2O, Na+, and Cl- were calculated. Each experiment consisted of three 1-hr periods: basal, luminal agent infusion, and recovery. Luminal adrenergic agents did not alter heart rate. Norepinephrine (α1 > α2 and β adrenergic agonist) and phenylephrine (α1 adrenergic agonist) caused significant absorption of water and sodium. Clonidine (α2 adrenergic agonist) and isoproterenol (β adrenergic agonist) caused significant secretion of water, sodium, and chloride. Luminally administered adrenergic agents can influence small intestinal water and electrolyte transport. Alpha1 agonists have a proabsorptive effect, while α2 and β agonists have a secretory effect. Luminally administered proabsorptive adrenergic agents may prove useful in pathologic secretory states such as diabetic diarrhea, small bowel transplantation, or diarrhea-associated endocrinopathies.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalJournal of Surgical Research
Volume46
Issue number5
DOIs
StatePublished - 1989

Fingerprint

Adrenergic Agonists
Adrenergic Agents
Water
Electrolytes
Diarrhea
Isotonic Solutions
Neural Pathways
Clonidine
Phenylephrine
Isoproterenol
Sodium Chloride
Norepinephrine
Transplantation
Heart Rate
Sodium
Dogs

ASJC Scopus subject areas

  • Surgery

Cite this

Bastidas, J. A., Schmieg, R. E., Yeo, C. J., & Zinner, M. J. (1989). Luminal adrenergic agents modulate intestinal transport. Journal of Surgical Research, 46(5), 484-489. https://doi.org/10.1016/0022-4804(89)90165-0

Luminal adrenergic agents modulate intestinal transport. / Bastidas, J. Augusto; Schmieg, Robert E.; Yeo, Charles J.; Zinner, Michael J.

In: Journal of Surgical Research, Vol. 46, No. 5, 1989, p. 484-489.

Research output: Contribution to journalArticle

Bastidas, JA, Schmieg, RE, Yeo, CJ & Zinner, MJ 1989, 'Luminal adrenergic agents modulate intestinal transport', Journal of Surgical Research, vol. 46, no. 5, pp. 484-489. https://doi.org/10.1016/0022-4804(89)90165-0
Bastidas, J. Augusto ; Schmieg, Robert E. ; Yeo, Charles J. ; Zinner, Michael J. / Luminal adrenergic agents modulate intestinal transport. In: Journal of Surgical Research. 1989 ; Vol. 46, No. 5. pp. 484-489.
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