TY - JOUR
T1 - Luminal adrenergic agents modulate intestinal transport
AU - Bastidas, J. Augusto
AU - Schmieg, Robert E.
AU - Yeo, Charles J.
AU - Zinner, Michael J.
PY - 1989/5
Y1 - 1989/5
N2 - Intestinal transport is controlled by luminal solutes, neural pathways, and paracrine or humoral agents. The current study investigated the effect of luminally administered adrenergic agents on the intestinal transport of water and electrolytes. Dogs with 25-cm jejunal Thiry-Vella loops were studied. The loops were luminally perfused with an isotonic solution containing [14C]PEG, and the fluxes of H2O, Na+, and Cl- were calculated. Each experiment consisted of three 1-hr periods: basal, luminal agent infusion, and recovery. Luminal adrenergic agents did not alter heart rate. Norepinephrine (α1 > α2 and β adrenergic agonist) and phenylephrine (α1 adrenergic agonist) caused significant absorption of water and sodium. Clonidine (α2 adrenergic agonist) and isoproterenol (β adrenergic agonist) caused significant secretion of water, sodium, and chloride. Luminally administered adrenergic agents can influence small intestinal water and electrolyte transport. Alpha1 agonists have a proabsorptive effect, while α2 and β agonists have a secretory effect. Luminally administered proabsorptive adrenergic agents may prove useful in pathologic secretory states such as diabetic diarrhea, small bowel transplantation, or diarrhea-associated endocrinopathies.
AB - Intestinal transport is controlled by luminal solutes, neural pathways, and paracrine or humoral agents. The current study investigated the effect of luminally administered adrenergic agents on the intestinal transport of water and electrolytes. Dogs with 25-cm jejunal Thiry-Vella loops were studied. The loops were luminally perfused with an isotonic solution containing [14C]PEG, and the fluxes of H2O, Na+, and Cl- were calculated. Each experiment consisted of three 1-hr periods: basal, luminal agent infusion, and recovery. Luminal adrenergic agents did not alter heart rate. Norepinephrine (α1 > α2 and β adrenergic agonist) and phenylephrine (α1 adrenergic agonist) caused significant absorption of water and sodium. Clonidine (α2 adrenergic agonist) and isoproterenol (β adrenergic agonist) caused significant secretion of water, sodium, and chloride. Luminally administered adrenergic agents can influence small intestinal water and electrolyte transport. Alpha1 agonists have a proabsorptive effect, while α2 and β agonists have a secretory effect. Luminally administered proabsorptive adrenergic agents may prove useful in pathologic secretory states such as diabetic diarrhea, small bowel transplantation, or diarrhea-associated endocrinopathies.
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U2 - 10.1016/0022-4804(89)90165-0
DO - 10.1016/0022-4804(89)90165-0
M3 - Article
C2 - 2716306
AN - SCOPUS:0024374987
SN - 0022-4804
VL - 46
SP - 484
EP - 489
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 5
ER -