Lumican inhibits SNAIL-induced melanoma cell migration specifically by blocking MMP-14 activity

Marta Stasiak, Joanna Boncela, Corinne Perreau, Konstantina Karamanou, Aurore Chatron-Colliet, Isabelle Proult, Patrycja Przygodzka, Shukti Chakravarti, François Xavier Maquart, M. Anna Kowalska, Yanusz Wegrowski, Stéphane Brézillon

Research output: Contribution to journalArticlepeer-review

Abstract

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.

Original languageEnglish (US)
Article numbere0150226
JournalPLoS One
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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