LSD1 and the chemistry of histone demethylation

Jeffrey C. Culhane, Philip A. Cole

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.

Original languageEnglish (US)
Pages (from-to)561-568
Number of pages8
JournalCurrent Opinion in Chemical Biology
Issue number5
StatePublished - Oct 2007
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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