Abstract
The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the basis for LSD1 substrate site specificity and the newly emerging potential for inhibition of these enzymes in structural and functional analysis.
Original language | English (US) |
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Pages (from-to) | 561-568 |
Number of pages | 8 |
Journal | Current Opinion in Chemical Biology |
Volume | 11 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry