LRP5 gene polymorphism and cortical bone

Fulvio Lauretani, Chiara Cepollaro, Stefania Bandinelli, Antonio Cherubini, Alessia Gozzini, Laura Masi, Alberto Falchetti, Francesca Del Monte, Silvia Carbonell-Sala, Francesca Marini, Annalisa Tanini, Anna Maria Corsi, Gian Paolo Ceda, Maria Luisa Brandi, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background and aims: There is evidence that distinct genetic polymorphisms of LRP5 are associated with low Bone Mineral Density (BMD) and the risk of fracture. However, relationships between LRP5 polymorphisms and micro- and macroarchitectural bone characteristics assessed by pQCT have not been studied. The aim of the present study was to investigate the association of Ala1330Val and Val667Met polymorphisms in LRP5 gene with volumetric BMD (vBMD) and macro-architectural bone parameters in a population-based sample of men and women. Methods: We studied 959 participants of the InCHIANTI study (451 men and 508 women, age range: 21-94 yrs). Trabecular vBMD (vBMDt, mg/cm3), cortical vBMD (vBMDc, mg/cm3), cortical bone area (CBA, mm 2) and cortical thickness (Ct.Th, mm) at the level of the tibia were assessed by peripheral quantitative computed tomography (pQCT). Ala1330Val and Val667Met genotypes were determined on genomic DNA by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: In age-adjusted analyses both LRP 1330-valine and LRP 667-metionin variants were associated with lower vBMDt in men (p

Original languageEnglish (US)
Pages (from-to)281-288
Number of pages8
JournalAging clinical and experimental research
Volume22
Issue number4
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Cortical bone area
  • LRP5 gene polymorphism
  • Osteoporosis
  • Peripheral bone quantitative computed tomography (pQCT)
  • Volumetric BMD

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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  • Cite this

    Lauretani, F., Cepollaro, C., Bandinelli, S., Cherubini, A., Gozzini, A., Masi, L., Falchetti, A., Del Monte, F., Carbonell-Sala, S., Marini, F., Tanini, A., Corsi, A. M., Ceda, G. P., Brandi, M. L., & Ferrucci, L. (2010). LRP5 gene polymorphism and cortical bone. Aging clinical and experimental research, 22(4), 281-288.