Abstract
One hundred and seven smears demonstrating a low‐grade squamous intraepithelial lesion (LSIL) were analyzed for features predicting subsequent biopsy confirmation. Twelve (29%) of 41 smears showing few LSIL cells were biopsy confirmed compared to 33 (60%) of 55 containing an intermediate number of LSIL cells and 9 (82%) of 11 displaying many LSIL cells (P < 0.002). Thirty‐seven (47%) of 78 smears showing mainly condylomatous atypia (CA), 7 (54%) of 13 revealing predominantly cervical intraepithelial neoplasia 1 (CIN 1), and 10 (63%) of 16 displaying both CA and CIN 1 were histologically confirmed (N.S.). Biopsy confirmation was obtained in 35 (65%) of 54 women whose repeat smears obtained at colposcopy demonstrated SIL compared to four (15%) of 26 patients whose repeat smears were normal or contained atypical squamous cells of undetermined significance (P < 0.001). These results suggest that the number of diagnostic cells in an LSIL smear predicts biopsy confirmation and affirm the validity of combining CA and CIN 1 under the category of LSIL in the Bethesda System. © 1994 Wiley‐Liss, Inc.
Original language | English (US) |
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Pages (from-to) | 3-9 |
Number of pages | 7 |
Journal | Diagnostic cytopathology |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1994 |
Keywords
- Cervical carcinoma
- Cervical intraepithelial neoplasia
- Cervix
- Colposcopy
- Condyloma
- Cytology
- Human papillomavirus
- In situ hybridization
- Squamous intraepithelial lesion
- The Bethesda System
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology