Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection - The Hawaii aging with HIV cohort

Victor Valcour, Priscilla Yee, Andrew E. Williams, Bruce Shiramizu, Michael Watters, Ola Selnes, Robert Paul, Cecilia Shikuma, Ned Sacktor

Research output: Contribution to journalArticlepeer-review

Abstract

Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a igh degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001).

Original languageEnglish (US)
Pages (from-to)387-391
Number of pages5
JournalJournal of neurovirology
Volume12
Issue number5
DOIs
StatePublished - Oct 2006

Keywords

  • AIDS dementia complex
  • CD4 lymphocyte count
  • Polyneuropathies

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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