Lowered Aortic Impedance as Therapy for Severe Mitral Regurgitation

William Grossman, Charles W. Harshaw, Alan B. Munro, Lewis Becker, Lambert P. McLaurin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Sodium nitroprusside was administered intravenously to a patient critically ill with severe mitral insufficiency caused by leakage around a prosthetic mitral valve. Cardiac index increased (1.3 to 3.2 liters/min/sq m) and regurgitant fraction and volume decreased (0.93 to 0.74 for regurgitant fraction, and 16.1 liters/min/sq m to 9.8 liters/min/sq m for regurgitant volume), in association with dramatic clinical improvement. It is suggested that nitroprusside therapy, by decreasing impedance to forward left ventricular output, may be of particular benefit to patients with severe mitral regurgitation.

Original languageEnglish (US)
Pages (from-to)1011-1013
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Issue number7
StatePublished - Nov 18 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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