TY - JOUR
T1 - Lowered Aortic Impedance as Therapy for Severe Mitral Regurgitation
AU - Grossman, William
AU - Harshaw, Charles W.
AU - Munro, Alan B.
AU - Becker, Lewis
AU - McLaurin, Lambert P.
PY - 1974/11/18
Y1 - 1974/11/18
N2 - Sodium nitroprusside was administered intravenously to a patient critically ill with severe mitral insufficiency caused by leakage around a prosthetic mitral valve. Cardiac index increased (1.3 to 3.2 liters/min/sq m) and regurgitant fraction and volume decreased (0.93 to 0.74 for regurgitant fraction, and 16.1 liters/min/sq m to 9.8 liters/min/sq m for regurgitant volume), in association with dramatic clinical improvement. It is suggested that nitroprusside therapy, by decreasing impedance to forward left ventricular output, may be of particular benefit to patients with severe mitral regurgitation.
AB - Sodium nitroprusside was administered intravenously to a patient critically ill with severe mitral insufficiency caused by leakage around a prosthetic mitral valve. Cardiac index increased (1.3 to 3.2 liters/min/sq m) and regurgitant fraction and volume decreased (0.93 to 0.74 for regurgitant fraction, and 16.1 liters/min/sq m to 9.8 liters/min/sq m for regurgitant volume), in association with dramatic clinical improvement. It is suggested that nitroprusside therapy, by decreasing impedance to forward left ventricular output, may be of particular benefit to patients with severe mitral regurgitation.
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U2 - 10.1001/jama.1974.03240070045028
DO - 10.1001/jama.1974.03240070045028
M3 - Article
C2 - 4479573
AN - SCOPUS:84942184996
SN - 0098-7484
VL - 230
SP - 1011
EP - 1013
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 7
ER -